Loading…

Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis

The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. We found that Pim-1 and Pim-2 are targets for the gp130-mediated STAT3 signal. Expression of a kinase-defective Pim-1 mutant attenuated gp130-mediated cell proliferation....

Full description

Saved in:

Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Mass.), 1999-12, Vol.11 (6), p.709-719
Main Authors:	Shirogane, Takahiro, Fukada, Toshiyuki, Muller, Joyce M.M, Shima, David T, Hibi, Masahiko, Hirano, Toshio
Format:	Article
Language:	English
Subjects:	Adenosine Triphosphatases Animals Antigens, CD - genetics Antigens, CD - metabolism Apoptosis B-Lymphocytes - cytology c-Myc protein Cell Cycle - physiology Cell Cycle Proteins - metabolism Cell Line Cytokine Receptor gp130 cytokine receptors DNA-Binding Proteins - metabolism glycoprotein gp130 Humans Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Pim-1 protein Pim-2 protein Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - physiology Proto-Oncogene Proteins c-pim-1 Signal Transduction Stat3 protein STAT3 Transcription Factor Trans-Activators - metabolism Tumor Cells, Cultured Valosin Containing Protein valosine-containing protein
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c557t-72f39d0fcbca990542007518029a968b6390a0dca4ebc18667069843865fcf753
cites	cdi_FETCH-LOGICAL-c557t-72f39d0fcbca990542007518029a968b6390a0dca4ebc18667069843865fcf753
container_end_page	719
container_issue	6
container_start_page	709
container_title	Immunity (Cambridge, Mass.)
container_volume	11
creator	Shirogane, Takahiro Fukada, Toshiyuki Muller, Joyce M.M Shima, David T Hibi, Masahiko Hirano, Toshio
description	The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. We found that Pim-1 and Pim-2 are targets for the gp130-mediated STAT3 signal. Expression of a kinase-defective Pim-1 mutant attenuated gp130-mediated cell proliferation. Constitutive expression of Pim-1 together with c-myc, another STAT3 target, fully compensated for loss of the STAT3-mediated cell cycle progression, antiapoptosis, and bcl-2 expression. We also identified valosine-containing protein ( VCP) as a target gene for the Pim-1-mediated signal. Expression of a mutant VCP led cells to undergo apoptosis. These results indicate that Pim-family proteins play crucial roles in gp130-mediated cell proliferation and explain the synergy between Pim and c-Myc proteins in cell proliferation and lymphomagenesis.
doi_str_mv	10.1016/S1074-7613(00)80145-4
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69397373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1074761300801454</els_id><sourcerecordid>69397373</sourcerecordid><originalsourceid>FETCH-LOGICAL-c557t-72f39d0fcbca990542007518029a968b6390a0dca4ebc18667069843865fcf753</originalsourceid><addsrcrecordid>eNqFkUtPGzEUha0KVCjlJ7TyCtGF4Tp-jVdVFPWBlIioCWvX8dxBribj1J4g5d8zeSzYsbp38Z37OIeQLxzuOHB9v-BgJDOai1uAbxVwqZj8QC45WMMkr-Bs35-QC_KplH-whyx8JBcc9EhXVlySv4tdh_k5lj4G-ie1WGiTMp3HNePUdzUNbLYLNHZ0sRwvBZthHX2PNZ1g29LJLrRI5zk9Zywlpu4gGXd99Ju06VOJ5TM5b3xb8PpUr8jTzx_LyW82ffz1MBlPWVDK9MyMGmFraMIqeGtByRGAUcMbI-utrlZaWPBQBy9xFXiltQFtKykqrZrQGCWuyM1x7ian_1ssvVvHEoYjfYdpW5y2whphxLsgN1JVmvMBVEcw5FRKxsZtclz7vHMc3D4Dd8jA7Q12AO6QgZOD7utpwXa1xvqN6mj6AHw_Ajj48RIxuxIidmGwNmPoXZ3iOyteAXdvk-8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17458611</pqid></control><display><type>article</type><title>Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Shirogane, Takahiro ; Fukada, Toshiyuki ; Muller, Joyce M.M ; Shima, David T ; Hibi, Masahiko ; Hirano, Toshio</creator><creatorcontrib>Shirogane, Takahiro ; Fukada, Toshiyuki ; Muller, Joyce M.M ; Shima, David T ; Hibi, Masahiko ; Hirano, Toshio</creatorcontrib><description>The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. We found that Pim-1 and Pim-2 are targets for the gp130-mediated STAT3 signal. Expression of a kinase-defective Pim-1 mutant attenuated gp130-mediated cell proliferation. Constitutive expression of Pim-1 together with c-myc, another STAT3 target, fully compensated for loss of the STAT3-mediated cell cycle progression, antiapoptosis, and bcl-2 expression. We also identified valosine-containing protein ( VCP) as a target gene for the Pim-1-mediated signal. Expression of a mutant VCP led cells to undergo apoptosis. These results indicate that Pim-family proteins play crucial roles in gp130-mediated cell proliferation and explain the synergy between Pim and c-Myc proteins in cell proliferation and lymphomagenesis.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/S1074-7613(00)80145-4</identifier><identifier>PMID: 10626893</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenosine Triphosphatases ; Animals ; Antigens, CD - genetics ; Antigens, CD - metabolism ; Apoptosis ; B-Lymphocytes - cytology ; c-Myc protein ; Cell Cycle - physiology ; Cell Cycle Proteins - metabolism ; Cell Line ; Cytokine Receptor gp130 ; cytokine receptors ; DNA-Binding Proteins - metabolism ; glycoprotein gp130 ; Humans ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - metabolism ; Mice ; Pim-1 protein ; Pim-2 protein ; Protein-Serine-Threonine Kinases ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins - physiology ; Proto-Oncogene Proteins c-myc - genetics ; Proto-Oncogene Proteins c-myc - physiology ; Proto-Oncogene Proteins c-pim-1 ; Signal Transduction ; Stat3 protein ; STAT3 Transcription Factor ; Trans-Activators - metabolism ; Tumor Cells, Cultured ; Valosin Containing Protein ; valosine-containing protein</subject><ispartof>Immunity (Cambridge, Mass.), 1999-12, Vol.11 (6), p.709-719</ispartof><rights>1999 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-72f39d0fcbca990542007518029a968b6390a0dca4ebc18667069843865fcf753</citedby><cites>FETCH-LOGICAL-c557t-72f39d0fcbca990542007518029a968b6390a0dca4ebc18667069843865fcf753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10626893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shirogane, Takahiro</creatorcontrib><creatorcontrib>Fukada, Toshiyuki</creatorcontrib><creatorcontrib>Muller, Joyce M.M</creatorcontrib><creatorcontrib>Shima, David T</creatorcontrib><creatorcontrib>Hibi, Masahiko</creatorcontrib><creatorcontrib>Hirano, Toshio</creatorcontrib><title>Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. We found that Pim-1 and Pim-2 are targets for the gp130-mediated STAT3 signal. Expression of a kinase-defective Pim-1 mutant attenuated gp130-mediated cell proliferation. Constitutive expression of Pim-1 together with c-myc, another STAT3 target, fully compensated for loss of the STAT3-mediated cell cycle progression, antiapoptosis, and bcl-2 expression. We also identified valosine-containing protein ( VCP) as a target gene for the Pim-1-mediated signal. Expression of a mutant VCP led cells to undergo apoptosis. These results indicate that Pim-family proteins play crucial roles in gp130-mediated cell proliferation and explain the synergy between Pim and c-Myc proteins in cell proliferation and lymphomagenesis.</description><subject>Adenosine Triphosphatases</subject><subject>Animals</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - metabolism</subject><subject>Apoptosis</subject><subject>B-Lymphocytes - cytology</subject><subject>c-Myc protein</subject><subject>Cell Cycle - physiology</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Line</subject><subject>Cytokine Receptor gp130</subject><subject>cytokine receptors</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>glycoprotein gp130</subject><subject>Humans</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Mice</subject><subject>Pim-1 protein</subject><subject>Pim-2 protein</subject><subject>Protein-Serine-Threonine Kinases</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Proto-Oncogene Proteins c-myc - physiology</subject><subject>Proto-Oncogene Proteins c-pim-1</subject><subject>Signal Transduction</subject><subject>Stat3 protein</subject><subject>STAT3 Transcription Factor</subject><subject>Trans-Activators - metabolism</subject><subject>Tumor Cells, Cultured</subject><subject>Valosin Containing Protein</subject><subject>valosine-containing protein</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkUtPGzEUha0KVCjlJ7TyCtGF4Tp-jVdVFPWBlIioCWvX8dxBribj1J4g5d8zeSzYsbp38Z37OIeQLxzuOHB9v-BgJDOai1uAbxVwqZj8QC45WMMkr-Bs35-QC_KplH-whyx8JBcc9EhXVlySv4tdh_k5lj4G-ie1WGiTMp3HNePUdzUNbLYLNHZ0sRwvBZthHX2PNZ1g29LJLrRI5zk9Zywlpu4gGXd99Ju06VOJ5TM5b3xb8PpUr8jTzx_LyW82ffz1MBlPWVDK9MyMGmFraMIqeGtByRGAUcMbI-utrlZaWPBQBy9xFXiltQFtKykqrZrQGCWuyM1x7ian_1ssvVvHEoYjfYdpW5y2whphxLsgN1JVmvMBVEcw5FRKxsZtclz7vHMc3D4Dd8jA7Q12AO6QgZOD7utpwXa1xvqN6mj6AHw_Ajj48RIxuxIidmGwNmPoXZ3iOyteAXdvk-8</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Shirogane, Takahiro</creator><creator>Fukada, Toshiyuki</creator><creator>Muller, Joyce M.M</creator><creator>Shima, David T</creator><creator>Hibi, Masahiko</creator><creator>Hirano, Toshio</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis</title><author>Shirogane, Takahiro ; Fukada, Toshiyuki ; Muller, Joyce M.M ; Shima, David T ; Hibi, Masahiko ; Hirano, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-72f39d0fcbca990542007518029a968b6390a0dca4ebc18667069843865fcf753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenosine Triphosphatases</topic><topic>Animals</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - metabolism</topic><topic>Apoptosis</topic><topic>B-Lymphocytes - cytology</topic><topic>c-Myc protein</topic><topic>Cell Cycle - physiology</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Line</topic><topic>Cytokine Receptor gp130</topic><topic>cytokine receptors</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>glycoprotein gp130</topic><topic>Humans</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Mice</topic><topic>Pim-1 protein</topic><topic>Pim-2 protein</topic><topic>Protein-Serine-Threonine Kinases</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins - physiology</topic><topic>Proto-Oncogene Proteins c-myc - genetics</topic><topic>Proto-Oncogene Proteins c-myc - physiology</topic><topic>Proto-Oncogene Proteins c-pim-1</topic><topic>Signal Transduction</topic><topic>Stat3 protein</topic><topic>STAT3 Transcription Factor</topic><topic>Trans-Activators - metabolism</topic><topic>Tumor Cells, Cultured</topic><topic>Valosin Containing Protein</topic><topic>valosine-containing protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shirogane, Takahiro</creatorcontrib><creatorcontrib>Fukada, Toshiyuki</creatorcontrib><creatorcontrib>Muller, Joyce M.M</creatorcontrib><creatorcontrib>Shima, David T</creatorcontrib><creatorcontrib>Hibi, Masahiko</creatorcontrib><creatorcontrib>Hirano, Toshio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shirogane, Takahiro</au><au>Fukada, Toshiyuki</au><au>Muller, Joyce M.M</au><au>Shima, David T</au><au>Hibi, Masahiko</au><au>Hirano, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>11</volume><issue>6</issue><spage>709</spage><epage>719</epage><pages>709-719</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. We found that Pim-1 and Pim-2 are targets for the gp130-mediated STAT3 signal. Expression of a kinase-defective Pim-1 mutant attenuated gp130-mediated cell proliferation. Constitutive expression of Pim-1 together with c-myc, another STAT3 target, fully compensated for loss of the STAT3-mediated cell cycle progression, antiapoptosis, and bcl-2 expression. We also identified valosine-containing protein ( VCP) as a target gene for the Pim-1-mediated signal. Expression of a mutant VCP led cells to undergo apoptosis. These results indicate that Pim-family proteins play crucial roles in gp130-mediated cell proliferation and explain the synergy between Pim and c-Myc proteins in cell proliferation and lymphomagenesis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10626893</pmid><doi>10.1016/S1074-7613(00)80145-4</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 1074-7613
ispartof	Immunity (Cambridge, Mass.), 1999-12, Vol.11 (6), p.709-719
issn	1074-7613 1097-4180
language	eng
recordid	cdi_proquest_miscellaneous_69397373
source	BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
subjects	Adenosine Triphosphatases Animals Antigens, CD - genetics Antigens, CD - metabolism Apoptosis B-Lymphocytes - cytology c-Myc protein Cell Cycle - physiology Cell Cycle Proteins - metabolism Cell Line Cytokine Receptor gp130 cytokine receptors DNA-Binding Proteins - metabolism glycoprotein gp130 Humans Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Pim-1 protein Pim-2 protein Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - physiology Proto-Oncogene Proteins c-pim-1 Signal Transduction Stat3 protein STAT3 Transcription Factor Trans-Activators - metabolism Tumor Cells, Cultured Valosin Containing Protein valosine-containing protein
title	Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T23%3A38%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synergistic%20Roles%20for%20Pim-1%20and%20c-Myc%20in%20STAT3-Mediated%20Cell%20Cycle%20Progression%20and%20Antiapoptosis&rft.jtitle=Immunity%20(Cambridge,%20Mass.)&rft.au=Shirogane,%20Takahiro&rft.date=1999-12-01&rft.volume=11&rft.issue=6&rft.spage=709&rft.epage=719&rft.pages=709-719&rft.issn=1074-7613&rft.eissn=1097-4180&rft_id=info:doi/10.1016/S1074-7613(00)80145-4&rft_dat=%3Cproquest_cross%3E69397373%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c557t-72f39d0fcbca990542007518029a968b6390a0dca4ebc18667069843865fcf753%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17458611&rft_id=info:pmid/10626893&rfr_iscdi=true