Factors affecting live birth rate in intrauterine insemination cycles with recombinant gonadotrophin stimulation

Abstract The objective of this cross-sectional study was to identify the prognostic factors that influence the outcome of ovarian stimulation with intrauterine insemination (IUI) cycles using gonadotrophins in couples with unexplained and mild male-factor subfertility. A total of 838 cycles in 456 w...

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Bibliographic Details
Published in:Reproductive biomedicine online 2008, Vol.17 (2), p.199-206
Main Authors: Erdem, Ahmet, Erdem, Mehmet, Atmaca, Songul, Korucuoglu, Umit, Karabacak, Onur
Format: Article
Language:English
Subjects:
Adult
clinical pregnancy
Cross-Sectional Studies
Female
Gonadotropins - therapeutic use
Humans
Infertility - diagnosis
Infertility - therapy
Insemination, Artificial - methods
intrauterine insemination
live birth rate
Male
male factor
Middle Aged
Obstetrics and Gynecology
Ovulation Induction - methods
Pregnancy
Pregnancy Rate
Prognosis
recombinant gonadotrophins
Recombinant Proteins - therapeutic use
Retrospective Studies
unexplained subfertility
Uterus - drug effects
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Summary:Abstract The objective of this cross-sectional study was to identify the prognostic factors that influence the outcome of ovarian stimulation with intrauterine insemination (IUI) cycles using gonadotrophins in couples with unexplained and mild male-factor subfertility. A total of 838 cycles in 456 women with unexplained and mild male-factor subfertility attending a university-based infertility clinic was evaluated. Of these cycles, 139 resulted in pregnancy (16.6% per cycle) and 96 out of 98 ongoing pregnancies resulted in live term birth. Live birth rate per patient and per cycle was 21.1% and 11.4%, respectively. Multivariate logistic regression analysis demonstrated that duration of infertility ( P = 0.034), type of infertility ( P = 0.003), aetiology of infertility ( P = 0.004), number of treatment cycles ( P = 0.0001) and number of dominant follicles before human chorionic gonadotrophin (HCG; P = 0.024) were significant independent factors to predict clinical pregnancy. The duration of infertility ( P = 0.043), number of treatment cycles ( P = 0.0001) and number of dominant follicles before HCG ( P = 0.024) were significant independent factors to predict live birth. In conclusion, for subfertile couples having shorter duration of subfertility, multifollicular response to gonadotrophins and in their first treatment cycle are more likely to succeed a live birth with IUI treatment using recombinant gonadotrophins.
ISSN:1472-6483
1472-6491
DOI:10.1016/S1472-6483(10)60195-2