Effect of Acute and Chronic Administration of Sodium Valproate on Lipid Peroxidation and Antioxidant System in Rat Liver

Changes in glutathione and lipid peroxide levels as well as in the activities of superoxide dismutase, glutathione peroxidase, catalase and glutathione‐S‐transferase have been studied in rats after acute and chronic sodium valproate treatments. Glutathione levels were decreased only after acute sodi...

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Bibliographic Details
Published in:Pharmacology & toxicology 1999-12, Vol.85 (6), p.294-298
Main Authors: Seçkin, Şule, Başaran‐Küçükgergin, Canan, Uysal, Müjdat
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Biological and medical sciences
Catalase - metabolism
Drug toxicity and drugs side effects treatment
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - enzymology
Liver - metabolism
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
Superoxide Dismutase - metabolism
Toxicity: digestive system
Valproic Acid - administration & dosage
Valproic Acid - pharmacology
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Summary:Changes in glutathione and lipid peroxide levels as well as in the activities of superoxide dismutase, glutathione peroxidase, catalase and glutathione‐S‐transferase have been studied in rats after acute and chronic sodium valproate treatments. Glutathione levels were decreased only after acute sodium valproate treatment. Neither acute nor chronic treatment influenced lipid peroxidation but induced glutathione‐S‐transferase activity significantly. On the other hand, no alterations in glutathione peroxidase and superoxide dismutase activities were found, except slight induction of catalase activity after acute administration of sodium valproate. These results indicate that sodium valproate treatment did not induce oxidative stress in the liver.
ISSN:0901-9928
1600-0773
DOI:10.1111/j.1600-0773.1999.tb02025.x