Submicromolar, Selective G-Quadruplex Ligands from One Pot: Thermodynamic and Structural Studies of Human Telomeric DNA Binding by Azacyanines

Bound to work: A molecular architecture with a shape that is slightly larger than a Watson–Crick base pair was investigated as a potential G‐quadruplex ligand. Azacyanines, which possess this architecture, were found to bind on the end of the quadruplex stack (as shown in the figure) and to exhibit...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2008-08, Vol.9 (12), p.1889-1892
Main Authors: Persil Çetinkol, Özgül, Engelhart, Aaron E, Nanjunda, Rupesh K, Wilson, W. David, Hud, Nicholas V
Format: Article
Language:English
Subjects:
Animals
Aza Compounds - chemistry
Aza Compounds - metabolism
Base Sequence
cancer
Cattle
DNA - chemistry
DNA - genetics
DNA - metabolism
DNA structures
drug design
G-Quadruplexes
Humans
Ligands
quadruplexes
Spectrometry, Fluorescence
Substrate Specificity
Telomere - genetics
telomeres
Thermodynamics
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Summary:Bound to work: A molecular architecture with a shape that is slightly larger than a Watson–Crick base pair was investigated as a potential G‐quadruplex ligand. Azacyanines, which possess this architecture, were found to bind on the end of the quadruplex stack (as shown in the figure) and to exhibit high selectivity over duplex binding. The chemical properties, ease of synthesis, and great potential for modification make the azacyanines and their analogues attractive for development as G‐quadruplex ligands in drug development.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200800234