Vanadium-vitamin B12 bioconjugates as potential therapeutics for treating diabetes

The synthesis and blood glucose lowering properties of the first vanadium-vitamin B(12) bioconjugates are reported.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2008-08 (32), p.3783-3785
Main Authors: Mukherjee, Riya, Donnay, Edward G, Radomski, Michal A, Miller, Catherine, Redfern, Duane A, Gericke, Arne, Damron, Derek S, Brasch, Nicola E
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Chromatography, High Pressure Liquid
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - drug therapy
Electron Spin Resonance Spectroscopy
Hypoglycemic Agents - chemical synthesis
Hypoglycemic Agents - therapeutic use
Magnetic Resonance Spectroscopy
Rats
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Vanadium Compounds - chemical synthesis
Vanadium Compounds - therapeutic use
Vitamin B 12 - chemical synthesis
Vitamin B 12 - therapeutic use
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Description
Summary:The synthesis and blood glucose lowering properties of the first vanadium-vitamin B(12) bioconjugates are reported.
ISSN:1359-7345
1364-548X
DOI:10.1039/b806598e