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Novel Terphenyls and 3,5-Diaryl Isoxazole Derivatives Endowed with Growth Supporting and Antiapoptotic Properties

A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing th...

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Bibliographic Details
Published in:Journal of medicinal chemistry 2008-08, Vol.51 (15), p.4796-4803
Main Authors: Simoni, Daniele, Rondanin, Riccardo, Baruchello, Riccardo, Rizzi, Michele, Grisolia, Giuseppina, Eleopra, Marco, Grimaudo, Stefania, Cristina, Antonietta Di, Pipitone, Maria Rosaria, Bongiorno, Maria Rita, Aricò€, Mario, Invidiata, Francesco Paolo, Tolomeo, Manlio
Format: Article
Language:English
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Summary:A new study on terphenyl and diaryl-isoxazole and -isoxazoline derivatives, maintaining a common 3-adamantyl-4-hydroxyphenyl moiety, has been conducted to find compounds with growth supporting and antiapoptotic properties. Unexpectedly, diphenyisoxazole derivatives bearing a nitro group replacing the carboxylic function have been found with the highest cell protective activity within the series, in complete and in serum-free conditions. Inhibition of apoptosis induced by daunorubicin has also been observed for the most active compound.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm800388m