Tenascin Expression and Angiogenesis in Breast Cancers

The expression and the distribution of tenascin as well as the extent of blood vessel formation (angiogenesis) were investigated in 70 invasive human breast carcinomas. Formalin-fixed, paraffin-embedded specimens were stained with monoclonal antibody against tenascin-C (DAKO and Biogenex). Anti-CD31...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 1999-01, Vol.195 (12), p.821-828
Main Authors: Tökés, Anna-Mária, Hortoványi, Eszter, Kulka, Janina, Jäkel, Márta, Kerényi, Tibor, Kádár, Anna
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angiogenesis
Breast cancer
Breast Neoplasms - blood supply
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - blood supply
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Female
Humans
Immunoenzyme Techniques
Ki-67 Antigen - metabolism
Middle Aged
Neoplasm Staging
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Prognosis
Receptors, Estrogen - metabolism
Tenascin
Tenascin - metabolism
Tumor Suppressor Protein p53 - metabolism
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Summary:The expression and the distribution of tenascin as well as the extent of blood vessel formation (angiogenesis) were investigated in 70 invasive human breast carcinomas. Formalin-fixed, paraffin-embedded specimens were stained with monoclonal antibody against tenascin-C (DAKO and Biogenex). Anti-CD31 antibody (Biogenex), an acknowledged marker of stromal angiogenesis, was used to detect endothelial cells. Tenascin immunostaining was positive in the tumours around the persisting normal ducts, around tumour-cell nests, in the neostroma, in some tumour cells, and it was found in or around vascular channels. Tumour vascularity was assessed by quantitative vascular grading (Chalkley point count) and was related to the localization and intensity of tenascin immunoreactivity. 19 tumours (27.1%) were scored as low, 35 (50%) as medium, and 16 (22.9%) as having a high vascular grade. The positive correlation between the vascular grade and the tenascin immunopositivity in tumour stroma was observed. Our results suggest that tenascin expression may be associated with endothelial cell activation and may play an important role in tumour angiogenesis.
ISSN:0344-0338
1618-0631
DOI:10.1016/S0344-0338(99)80104-6