Abnormal markers of endothelial cell activation and oxidative stress in children, adolescents and young adults with Type 1 diabetes with no clinical vascular disease

• Published in: Diabetes/metabolism research and reviews 1999-11, Vol.15 (6), p.405-411
• Main Authors: Elhadd, Tarik A., Kennedy, Gwen, Hill, Alexander, McLaren, Margaret, Newton, Ray W., Greene, Stephen A., Belch, Jill J. F.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biological and medical sciences; Biomarkers; CD13 Antigens - blood; cell adhesion molecules; Child; childhood diabetes; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - pathology; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - pathology; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - blood; E-selectin; E-Selectin - metabolism; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; endothelial dysfunction; Endothelium, Vascular - cytology; Endothelium, Vascular - physiopathology; Erythrocytes - metabolism; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Free Radicals - metabolism; Glutathione - blood; Humans; ICAM-1; Intercellular Adhesion Molecule-1 - metabolism; Male; Medical sciences; oxidative stress; Oxidative Stress - physiology; Sulfhydryl Compounds - blood; Superoxide Dismutase - metabolism; von Willebrand Factor; von Willebrand Factor - metabolism
• ISSN: 1520-7552; 1520-7560
• DOI: 10.1002/(SICI)1520-7560(199911/12)15:6<405::AID-DMRR69>3.0.CO;2-H

Background Endothelial cell dysfunction is an early feature of vascular disease and oxidative stress may be involved in its pathogenesis. Methods Fifty‐one children, adolescents and young people with Type 1 diabetes with no clinical diabetic angiopathy, mean age±SD of 16±4 years, diabetes duration of 8±5 years, and HbA1c of 8.5±1.6%, and 29 age, sex matched normal controls had blood samples assayed for E‐selectin, intercellular cell adhesion molecule‐1, von Willebrand Factor, red cell superoxide dismutase, plasma thiol and red cell glutathione. Results E‐selectin and ICAM‐1 levels were significantly higher in the diabetic patients at 72±24 ng/ml and 287±57 ng/ml, respectively vs 43±16 ng/ml and 248±71 ng/ml in the normal controls (p