Growth hormone response to baclofen in patients with mania : a pilot study

• Published in: Psychopharmacologia 1999-12, Vol.147 (3), p.280-284
• Main Authors: SHIAH, I.-Shin, YATHAM, Lakshmi N, LAM, Raymond W, TAM, Edwin M, ZIS, Athanasios P
• Format: Article
• Language: English
• Subjects: Acute Disease; Adult; Adult and adolescent clinical studies; Affective disorders; Area Under Curve; Baclofen; Baclofen - pharmacology; Biological and medical sciences; Bipolar Disorder - blood; Bipolar Disorder - psychology; Blood levels; Female; GABA Agonists - pharmacology; GABA-B Receptor Agonists; Growth hormones; Human Growth Hormone - blood; Humans; Hypothalamus; Male; Mania; Medical sciences; Mood disorders; Oral administration; Placebos; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptor mechanisms; Time Factors; γ-Aminobutyric acid B receptors
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/s002130051168

Growth hormone (GH) response to a challenge with a GABAB receptor agonist, baclofen, is considered to provide an in vivo index of hypothalamic GABAB receptor function in humans. The purpose of this study was to explore the role of GABAB receptors in the pathophysiology of mania by measuring plasma GH response to baclofen in ten manic patients and ten matched healthy controls. After obtaining blood samples for baseline GH levels, a single dose of 20 mg baclofen was administered orally to all the subjects, and further blood samples were obtained at 30-min intervals for the following 3 h. We found that baclofen administration led to a significant increase in GH release both in manic patients and healthy controls, but the GH response to baclofen in manic patients was significantly enhanced when compared to healthy controls. Our results suggest that manic patients may have an up-regulated hypothalamic GABAB receptor function. However, in light of the limitations including small sample size and absence of placebo control, our results should be viewed as preliminary. Further studies with a larger number of manic patients and a placebo control design are needed to replicate our finding before any firm conclusion can be drawn.