Double Dissociation of Function Within the Hippocampus: A Comparison of Dorsal, Ventral, and Complete Hippocampal Cytotoxic Lesions

Rats with complete cytotoxic hippocampal lesions exhibited spatial memory impairments in both the water maze and elevated T maze. They were hyperactive in photocell cages; swam faster in the water maze; and were less efficient on a nonspatial, differential reinforcement of low rates (DRL) task. Perf...

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Bibliographic Details
Published in:Behavioral neuroscience 1999-12, Vol.113 (6), p.1170-1188
Main Authors: Bannerman, D. M, Yee, B. K, Good, M. A, Heupel, M. J, Iversen, S. D, Rawlins, J. N. P
Format: Article
Language:English
Subjects:
Analysis of Variance
Anatomical correlates of behavior
Animal
Animal behavior
Animal cognition
Animals
Behavioral psychophysiology
Biological and medical sciences
Excitatory Amino Acid Antagonists - administration & dosage
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - injuries
Hippocampus - physiology
Hyperkinesis
Locomotion
Male
Maze Learning - physiology
Memory
Microinjections
N-Methylaspartate - administration & dosage
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Inbred Strains
Rodents
Space life sciences
Space Perception - physiology
Spatial Memory
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Summary:Rats with complete cytotoxic hippocampal lesions exhibited spatial memory impairments in both the water maze and elevated T maze. They were hyperactive in photocell cages; swam faster in the water maze; and were less efficient on a nonspatial, differential reinforcement of low rates (DRL) task. Performance on both spatial tasks was also impaired by selective dorsal but not ventral lesions; swim speed was increased by ventral but not dorsal lesions. Both partial lesions caused a comparable reduction in DRL efficiency, although these effects were smaller than those of complete lesions. Neither partial lesion induced hyperactivity when rats were tested in photocell cages, although both complete and ventral lesion groups showed increased activity after footshock in other studies ( Richmond et al., 1999 ). These results demonstrate possible functional dissociations along the septotemporal axis of the hippocampus.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.113.6.1170