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Double Dissociation of Function Within the Hippocampus: A Comparison of Dorsal, Ventral, and Complete Hippocampal Cytotoxic Lesions
Rats with complete cytotoxic hippocampal lesions exhibited spatial memory impairments in both the water maze and elevated T maze. They were hyperactive in photocell cages; swam faster in the water maze; and were less efficient on a nonspatial, differential reinforcement of low rates (DRL) task. Perf...
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| Published in: | Behavioral neuroscience 1999-12, Vol.113 (6), p.1170-1188 |
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| container_end_page | 1188 |
| container_issue | 6 |
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| container_title | Behavioral neuroscience |
| container_volume | 113 |
| creator | Bannerman, D. M Yee, B. K Good, M. A Heupel, M. J Iversen, S. D Rawlins, J. N. P |
| description | Rats with complete cytotoxic hippocampal lesions exhibited
spatial memory impairments in both the water maze and elevated T
maze. They were hyperactive in photocell cages; swam faster in the
water maze; and were less efficient on a nonspatial, differential
reinforcement of low rates (DRL) task. Performance on both spatial
tasks was also impaired by selective dorsal but not ventral lesions;
swim speed was increased by ventral but not dorsal lesions. Both
partial lesions caused a comparable reduction in DRL efficiency,
although these effects were smaller than those of complete lesions.
Neither partial lesion induced hyperactivity when rats were tested
in photocell cages, although both complete and ventral lesion groups
showed increased activity after footshock in other studies (
Richmond et al., 1999
). These results demonstrate possible
functional dissociations along the septotemporal axis of the
hippocampus. |
| doi_str_mv | 10.1037/0735-7044.113.6.1170 |
| format | article |
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spatial memory impairments in both the water maze and elevated T
maze. They were hyperactive in photocell cages; swam faster in the
water maze; and were less efficient on a nonspatial, differential
reinforcement of low rates (DRL) task. Performance on both spatial
tasks was also impaired by selective dorsal but not ventral lesions;
swim speed was increased by ventral but not dorsal lesions. Both
partial lesions caused a comparable reduction in DRL efficiency,
although these effects were smaller than those of complete lesions.
Neither partial lesion induced hyperactivity when rats were tested
in photocell cages, although both complete and ventral lesion groups
showed increased activity after footshock in other studies (
Richmond et al., 1999
). These results demonstrate possible
functional dissociations along the septotemporal axis of the
hippocampus.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.113.6.1170</identifier><identifier>PMID: 10636297</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Analysis of Variance ; Anatomical correlates of behavior ; Animal ; Animal behavior ; Animal cognition ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Excitatory Amino Acid Antagonists - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - injuries ; Hippocampus - physiology ; Hyperkinesis ; Locomotion ; Male ; Maze Learning - physiology ; Memory ; Microinjections ; N-Methylaspartate - administration & dosage ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Inbred Strains ; Rodents ; Space life sciences ; Space Perception - physiology ; Spatial Memory</subject><ispartof>Behavioral neuroscience, 1999-12, Vol.113 (6), p.1170-1188</ispartof><rights>1999 American Psychological Association</rights><rights>2000 INIST-CNRS</rights><rights>Copyright American Psychological Association Dec 1999</rights><rights>1999, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1216483$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10636297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bannerman, D. M</creatorcontrib><creatorcontrib>Yee, B. K</creatorcontrib><creatorcontrib>Good, M. A</creatorcontrib><creatorcontrib>Heupel, M. J</creatorcontrib><creatorcontrib>Iversen, S. D</creatorcontrib><creatorcontrib>Rawlins, J. N. P</creatorcontrib><title>Double Dissociation of Function Within the Hippocampus: A Comparison of Dorsal, Ventral, and Complete Hippocampal Cytotoxic Lesions</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Rats with complete cytotoxic hippocampal lesions exhibited
spatial memory impairments in both the water maze and elevated T
maze. They were hyperactive in photocell cages; swam faster in the
water maze; and were less efficient on a nonspatial, differential
reinforcement of low rates (DRL) task. Performance on both spatial
tasks was also impaired by selective dorsal but not ventral lesions;
swim speed was increased by ventral but not dorsal lesions. Both
partial lesions caused a comparable reduction in DRL efficiency,
although these effects were smaller than those of complete lesions.
Neither partial lesion induced hyperactivity when rats were tested
in photocell cages, although both complete and ventral lesion groups
showed increased activity after footshock in other studies (
Richmond et al., 1999
). These results demonstrate possible
functional dissociations along the septotemporal axis of the
hippocampus.</description><subject>Analysis of Variance</subject><subject>Anatomical correlates of behavior</subject><subject>Animal</subject><subject>Animal behavior</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Excitatory Amino Acid Antagonists - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - injuries</subject><subject>Hippocampus - physiology</subject><subject>Hyperkinesis</subject><subject>Locomotion</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Memory</subject><subject>Microinjections</subject><subject>N-Methylaspartate - administration & dosage</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - injuries</topic><topic>Hippocampus - physiology</topic><topic>Hyperkinesis</topic><topic>Locomotion</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Memory</topic><topic>Microinjections</topic><topic>N-Methylaspartate - administration & dosage</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Rodents</topic><topic>Space life sciences</topic><topic>Space Perception - physiology</topic><topic>Spatial Memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bannerman, D. M</creatorcontrib><creatorcontrib>Yee, B. K</creatorcontrib><creatorcontrib>Good, M. A</creatorcontrib><creatorcontrib>Heupel, M. J</creatorcontrib><creatorcontrib>Iversen, S. D</creatorcontrib><creatorcontrib>Rawlins, J. N. 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spatial memory impairments in both the water maze and elevated T
maze. They were hyperactive in photocell cages; swam faster in the
water maze; and were less efficient on a nonspatial, differential
reinforcement of low rates (DRL) task. Performance on both spatial
tasks was also impaired by selective dorsal but not ventral lesions;
swim speed was increased by ventral but not dorsal lesions. Both
partial lesions caused a comparable reduction in DRL efficiency,
although these effects were smaller than those of complete lesions.
Neither partial lesion induced hyperactivity when rats were tested
in photocell cages, although both complete and ventral lesion groups
showed increased activity after footshock in other studies (
Richmond et al., 1999
). These results demonstrate possible
functional dissociations along the septotemporal axis of the
hippocampus.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>10636297</pmid><doi>10.1037/0735-7044.113.6.1170</doi><tpages>19</tpages></addata></record> |
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| ispartof | Behavioral neuroscience, 1999-12, Vol.113 (6), p.1170-1188 |
| issn | 0735-7044 1939-0084 |
| language | eng |
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| source | EBSCOhost APA PsycARTICLES |
| subjects | Analysis of Variance Anatomical correlates of behavior Animal Animal behavior Animal cognition Animals Behavioral psychophysiology Biological and medical sciences Excitatory Amino Acid Antagonists - administration & dosage Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - injuries Hippocampus - physiology Hyperkinesis Locomotion Male Maze Learning - physiology Memory Microinjections N-Methylaspartate - administration & dosage Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Strains Rodents Space life sciences Space Perception - physiology Spatial Memory |
| title | Double Dissociation of Function Within the Hippocampus: A Comparison of Dorsal, Ventral, and Complete Hippocampal Cytotoxic Lesions |
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