Fatal disseminated infection by scedosporium prolificans during induction therapy for acute leukemia: a case report and literature review

We report a case of fatal disseminated fungal infection by Scedosporium prolificans which occurred in a patient with acute leukemia during induction chemotherapy. Rapid clinical deterioration despite highdose empirical amphotericin B highlights both the pathogenicity of this fungus in immunocompromi...

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Bibliographic Details
Published in:Pathology 1999-11, Vol.31 (4), p.393-394
Main Authors: Westerman, David A., Speed, Bryan R., Miles Prince, H.
Format: Article
Language:English
Subjects:
Acute leukemia
Aged
Amphotericin B - therapeutic use
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Cytarabine - therapeutic use
Daunorubicin - therapeutic use
Drug Resistance, Microbial
Drug toxicity and drugs side effects treatment
Fatal Outcome
Female
Fungemia - drug therapy
Fungemia - etiology
Humans
immunocompromised
Immunocompromised Host
Leukemia, Myeloid, Acute - drug therapy
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Mycetoma - drug therapy
Mycetoma - etiology
Pharmacology. Drug treatments
Pseudallescheria - isolation & purification
Pseudallescheria - pathogenicity
Scedosporium prolificans
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Summary:We report a case of fatal disseminated fungal infection by Scedosporium prolificans which occurred in a patient with acute leukemia during induction chemotherapy. Rapid clinical deterioration despite highdose empirical amphotericin B highlights both the pathogenicity of this fungus in immunocompromised hosts and its resistance to standard antifungal therapy.
ISSN:0031-3025
1465-3931
DOI:10.1080/003130299104783