Caveats of caveolin-1 in cancer progression

Abstract Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo . Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its...

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Bibliographic Details
Published in:Cancer letters 2008-09, Vol.268 (2), p.187-201
Main Authors: Burgermeister, Elke, Liscovitch, Mordechai, Röcken, Christoph, Schmid, Roland M, Ebert, Matthias P.A
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Apoptosis
Brain research
Cancer progression
Cancer therapies
Caveolin
Caveolin 1 - analysis
Caveolin 1 - physiology
Cell Adhesion
Cell Survival
Cholesterol
Disease Progression
Drug resistance
Extracellular Matrix - physiology
Gene expression
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Laboratories
Lipids
Lung cancer
Medical prognosis
Metastasis
Molecular weight
Neoplasm Metastasis
Neoplasms - etiology
Neoplasms - mortality
Neovascularization, Pathologic - etiology
Prognosis
Prostate cancer
Proteins
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Summary:Abstract Caveolin-1, an essential scaffold protein of caveolae and cellular transport processes, lately gained recognition as a stage- and tissue-specific tumor modulator in vivo . Patient studies and rodent models corroborated its janus-faced role as a tumor suppressor in non-neoplastic tissue, its down-regulation (loss of function) upon transformation and its re-expression (regain of function) in advanced-stage metastatic and multidrug resistant tumors. This review is focussed on the role of caveolin-1 in metastasis and angiogenesis and its clinical implications as a prognostic marker in cancer progression.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2008.03.055