A patient with clinicopathologic features of small plaque parapsoriasis presenting later with plaque-stage mycosis fungoides: Report of a case and comparative retrospective study of 27 cases of “nonprogressive” small plaque parapsoriasis

Background It is unsettled whether small plaque parapsoriasis (SPP) represents an inflammatory dermatosis or has a potential to transform into mycosis fungoides (MF) or is, in fact, MF. The literature contains no fully documented example of progression of SPP into MF. Objective The purpose of our st...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2008-09, Vol.59 (3), p.474-482
Main Authors: Belousova, Irena E., MD, PhD, Vanecek, Tomas, PhD, Samtsov, Alexey V., MD, DrSc, Michal, Michal, MD, Kazakov, Dmitry V., MD, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, CD - analysis
Clone Cells
Dermatology
Disease Progression
DNA - analysis
Female
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Humans
Immunohistochemistry
Immunophenotyping
Male
Middle Aged
Mycosis Fungoides - diagnosis
Mycosis Fungoides - etiology
Parapsoriasis - complications
Parapsoriasis - diagnosis
Parapsoriasis - immunology
Retrospective Studies
Skin - pathology
T-Lymphocytes - metabolism
T-Lymphocytes - pathology
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Summary:Background It is unsettled whether small plaque parapsoriasis (SPP) represents an inflammatory dermatosis or has a potential to transform into mycosis fungoides (MF) or is, in fact, MF. The literature contains no fully documented example of progression of SPP into MF. Objective The purpose of our study was to present a patient with clinical features of SPP who later developed plaque-stage MF, as seen both clinically and pathologically and to compare the clinicopathologic features of this unique case with 27 “nonprogressive” SPP cases. Methods This study is a prospective and retrospective evaluation of 28 patients, using light microscopy, immunohistochemistry, and molecular biology. Results A 56-year-old man with a 3-year history of persistent SPP with typical small (
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2008.05.028