Agrochelin, a New Cytotoxic Antibiotic from a Marine Agrobacterium: Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activity

Agrochelin, a new alkaloid cytotoxic substance, was produced by the fermentation of Agrobacterium sp. The compound was obtained from the bacterial cells by solvent extraction and purified by silica gel chromatography. Agrochelin (1) and its acetyl derivative (2) exhibited cytotoxic activity.

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Bibliographic Details
Published in:Journal of antibiotics 1999/11/25, Vol.52(11), pp.983-987
Main Authors: ACEBAL, CRISTINA, CAÑEDO, LIBRADA M., PUENTES, JOSÉ L. FERNÁNDEZ, BAZ, JULIA PÉREZ, ROMERO, FRANCISCO, CALLE, FERNANDO DE LA, GRÁVALOS, M. DOLORES GARCÍA, RODRIGUEZ, PILAR
Format: Article
Language:English
Subjects:
Agrobacterium
agrochelin
Animals
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic agents
Applied microbiology
Biological and medical sciences
Chemotherapic agents
Fermentation
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Marine
Medical sciences
Mice
Microbiology
Pharmacology. Drug treatments
Rhizobium - classification
Rhizobium - metabolism
Thiazoles - chemistry
Thiazoles - isolation & purification
Thiazoles - pharmacology
Tumor Cells, Cultured
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Description
Summary:Agrochelin, a new alkaloid cytotoxic substance, was produced by the fermentation of Agrobacterium sp. The compound was obtained from the bacterial cells by solvent extraction and purified by silica gel chromatography. Agrochelin (1) and its acetyl derivative (2) exhibited cytotoxic activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.52.983