Identification of FLRT1, FLRT2, and FLRT3: A Novel Family of Transmembrane Leucine-Rich Repeat Proteins

FLRT1, FLRT2, and FLRT3 comprise a novel gene family isolated in a screen for extracellular matrix proteins expressed in muscle. The three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats flanked by N-terminal and C-terminal cysteine-rich regions, a fibron...

Full description

Saved in:
Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1999-12, Vol.62 (3), p.417-426
Main Authors: Lacy, Susan E., Bönnemann, Carsten G., Buzney, Elizabeth A., Kunkel, Louis M.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Biological and medical sciences
Cell Line
chromosome 11
chromosome 14
chromosome 20
Chromosome Mapping
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 14 - genetics
Chromosomes, Human, Pair 20 - genetics
Cloning, Molecular
DNA, Complementary - analysis
extracellular matrix proteins
FLRT1 protein
FLRT2 protein
FLRT3 protein
Fundamental and applied biological sciences. Psychology
Gene Expression
Genes. Genome
Humans
leucine
Leucine - genetics
Membrane Proteins - chemistry
Membrane Proteins - genetics
Membrane Proteins - isolation & purification
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Multigene Family
Muscle, Skeletal - metabolism
Organ Specificity
Protein Structure, Tertiary - genetics
Repetitive Sequences, Amino Acid - genetics
RNA, Messenger - biosynthesis
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:FLRT1, FLRT2, and FLRT3 comprise a novel gene family isolated in a screen for extracellular matrix proteins expressed in muscle. The three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats flanked by N-terminal and C-terminal cysteine-rich regions, a fibronectin/collagen-like domain, and an intracellular tail. FLRT1 is expressed in kidney and brain, FLRT2 is expressed in pancreas, skeletal muscle, brain, and heart, and FLRT3 is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. FLRT1 localized to 11q12–q13, FLRT2 to 14q24–q32, and FLRT3 to 20p11. When expressed in SF9 and COS-1 cells, FLRT1 and FLRT2 migrate as 90- and 85-kDa proteins, respectively, and both are glycosylated. Given the overall structure of the three proteins, a function in cell adhesion and/or receptor signaling is predicted.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1999.6033