Type 2 Diabetes Mellitus and the Metabolic Syndrome Following Sleeve Gastrectomy in Severely Obese Subjects

• Published in: Obesity surgery 2008-09, Vol.18 (9), p.1077-1082
• Main Authors: Vidal, J., Ibarzabal, A., Romero, F., Delgado, S., Momblán, D., Flores, L., Lacy, A.
• Format: Article
• Language: English
• Subjects: Adult; Blood Glucose - metabolism; Clinical outcomes; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - prevention & control; Female; Follow-Up Studies; Gastrectomy; Gastric Bypass; Gastrointestinal surgery; Humans; Male; Medicine; Medicine & Public Health; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - metabolism; Metabolic Syndrome - prevention & control; Middle Aged; Obesity; Obesity, Morbid - complications; Obesity, Morbid - metabolism; Obesity, Morbid - surgery; Research Article; Surgery; Time Factors; Treatment Outcome; Weight Loss
• ISSN: 0960-8923; 1708-0428
• DOI: 10.1007/s11695-008-9547-2

Background Data on the effectiveness of sleeve gastrectomy in improving or resolving type 2 diabetes mellitus (T2DM) and the metabolic syndrome (MS) are scarce. Methods A twelve-month prospective study on the changes in glucose homeostasis and the MS in 91 severely obese T2DM subjects undergoing laparoscopic SG (SG; n  = 39) or laparoscopic Roux-en-Y gastric bypass (GBP; n  = 52), matched for DM duration, type of DM treatment, and glycemic control was conducted. Results At 12 months after surgery, subjects undergoing SG and GBP lost a similar amount of weight (%EBL: SG: 63.00 ± 2.89%, BPG: 66.06 ± 2.34%; p  = 0.413). On that evaluation, T2DM had resolved, respectively, in 33 out of 39 (84.6%) and 44 out of 52 (84.6%) subjects after SG and GBP ( p  = 0.618). The rate of resolution of the MS (SG: 62.2%, BPG: 67.3%; p  = 0.392) was also comparable. A shorter DM duration ( p