Antibacterial and antifungal flavanones from Eysenhardtia texana

• Published in: Phytochemistry (Oxford) 1999-12, Vol.52 (8), p.1469-1471
• Main Authors: Wächter, Gerald A., Hoffmann, Joseph J., Furbacher, Todd, Blake, Mary E., Timmermann, Barbara N.
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents; Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antibacterial; Antifungal; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Biological and medical sciences; Candida albicans - drug effects; Candida albicans - growth & development; Chemical constitution; Eysenhardtia texana; Fabaceae; flavanones; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Fundamental and applied biological sciences. Psychology; General pharmacology; Magnetic Resonance Spectroscopy; Medical sciences; Microbial Sensitivity Tests; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - analysis; Plant physiology and development; Plants - chemistry; Prenylated flavanones; Spectrometry, Mass, Secondary Ion; Staphylococcus aureus - drug effects; Staphylococcus aureus - growth & development
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(99)00221-6

An activity-guided fractionation of a methanol–dichloromethane extract obtained from the aerial parts of Eysenhardtia texana led to the isolation of two novel antibacterial and antifungal flavanones together with a known flavanone. Their structures were established as 4′,5,7-trihydroxy-8-methyl-6-(3-methyl-[2-butenyl])-(2 S)-flavanone, 4′,5,7-trihydroxy-6-methyl-8-(3-methyl-[2-butenyl])-(2 S)-flavanone and 4′,5-dihydroxy-7-methoxy-6-(3-methyl-[2-butenyl])-(2 S)-flavanone on the basis of their UV, 1D and 2D-NMR spectra.