Improvement of eosinophilic heart disease after steroid therapy: successful demonstration by endomyocardial biopsied specimens

A 62-year-old man with acute eosinophilic endomyocarditis developed congestive heart failure. The biopsy specimens revealed degranulated eosinophils and eosinophil cationic protein (ECP) in the endocardium, and in activated eosinophils and the myocardial interstitium. On electronmicroscopy, a charac...

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Bibliographic Details
Published in:Heart and vessels 1999-01, Vol.14 (2), p.104-108
Main Authors: Hayashi, S, Isobe, M, Okubo, Y, Suzuki, J, Yazaki, Y, Sekiguchi, M
Format: Article
Language:English
Subjects:
Biopsy
Glucocorticoids - therapeutic use
Heart Failure - etiology
Humans
Hypereosinophilic Syndrome - complications
Hypereosinophilic Syndrome - drug therapy
Hypereosinophilic Syndrome - pathology
Male
Middle Aged
Prednisolone - therapeutic use
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Summary:A 62-year-old man with acute eosinophilic endomyocarditis developed congestive heart failure. The biopsy specimens revealed degranulated eosinophils and eosinophil cationic protein (ECP) in the endocardium, and in activated eosinophils and the myocardial interstitium. On electronmicroscopy, a characteristic cardiac myocytolytic change showing disruption at the intercellular junctional site was observed. After steroid treatment, clinical symptoms, systolic dysfunction and laboratory data dramatically improved. In the subsequent biopsy specimens, eosinophilic infiltration and ECP disappeared. Steroid therapy provided a beneficial effect in preventing the progression of cardiac damage. This effect was clearly documented by histochemical studies of the serial endomyocardial biopsy samples.
ISSN:0910-8327
1615-2573
DOI:10.1007/bf02481750