Up-regulated thromboxane production in the rat liver with biliary obstruction does not contribute to promote hepatic injury

This study sought to determine whether in vivo inhibition of thromboxane A2 (TXA2) action contribute to attenuate hepatic damage after bile duct ligation (BDL). Male Wistar rats were assigned to sham operation or BDL. At the time of operation, infusion pump with saline, ozagrel natrium (TXA2 synthas...

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Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 2008-06, Vol.29 (6), p.688-691
Main Authors: Yokoyama, Yukihiro, Kawai, Toru, Kawai, Satoru, Kitagawa, Tomomi, Watanabe, Katsutaka, Kawai, Kiyotaka, Nagino, Masato
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Animals
Bilirubin - blood
Enzyme Inhibitors - pharmacology
Gene Expression Regulation, Enzymologic - drug effects
Hyaluronic Acid - blood
Hydrazines - pharmacology
Liver - enzymology
Liver - injuries
Liver - pathology
Liver Diseases - blood
Male
Methacrylates - pharmacology
Rats
Rats, Wistar
Receptors, Thromboxane A2, Prostaglandin H2 - antagonists & inhibitors
Thromboxane A2 - antagonists & inhibitors
Thromboxane A2 - blood
Thromboxane A2 - pharmacology
Thromboxane B2 - blood
Thromboxane-A Synthase - biosynthesis
Time Factors
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Summary:This study sought to determine whether in vivo inhibition of thromboxane A2 (TXA2) action contribute to attenuate hepatic damage after bile duct ligation (BDL). Male Wistar rats were assigned to sham operation or BDL. At the time of operation, infusion pump with saline, ozagrel natrium (TXA2 synthase inhibitor), or SQ29548 (TXA2 receptor antagonists) was implanted in the abdominal cavity. Plasma alanine aminotransferase, aspartate aminotransferase, hyaluronic acid, and total bilirubin levels were measured at 4 days after the operation. The levels of plasma TXB2, a stable metabolite of TXA2, were significantly increased after BDL. Gene expression of TXA2 synthase was also significantly upregulated in the liver. Nonetheless, either an inhibition of TXA2 synthesis by ozagrel natrium or a blockade of TXA2 receptor by SQ29548 has no effect in every measured parameter related to hepatic function. These results indicated that despite a highly increased production in the liver, TXA2 is not directly related to the hepatic injury in BDL rats.
ISSN:1073-2322
DOI:10.1097/SHK.0b013e31815812ff