Expression of the mucosal vascular addressin, MAdCAM-1, in inflammatory liver disease

: Aims/Background: The integrin α4β7 and mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1) are involved in normal recirculation of lymphocytes between the blood and the tissues of the gastrointestinal tract. In this study we have examined the expression of MAdCAM‐1 in human liver. Methods: MAdCA...

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Published in:Liver (Copenhagen) 1999-12, Vol.19 (6), p.509-518
Main Authors: Hillan, Kenneth J., Hagler, Kelly E., MacSween, Roderick N. M., Ryan, Anne M., Renz, Mark E., Chiu, Henry H., Ferrier, Rod K., Bird, George L., Dhillon, Amar P., Ferrell, Linda D., Fong, Sherman
Format: Article
Language:English
Subjects:
Animals
Antibody Specificity
Antigens, CD34 - metabolism
Binding Sites, Antibody
Biological and medical sciences
Cell interactions, adhesion
Enzyme-Linked Immunosorbent Assay
Fetus - metabolism
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
hepatitis
Hepatitis - metabolism
Hepatitis - pathology
Humans
Immunoenzyme Techniques
Immunoglobulins - metabolism
immunohistochemistry
integrin
Liver - metabolism
Liver - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Molecular and cellular biology
Mucoproteins - metabolism
Other diseases. Semiology
Rabbits
Receptors, Complement 3d - metabolism
Receptors, Lymphocyte Homing - metabolism
α4β7
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Summary:: Aims/Background: The integrin α4β7 and mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1) are involved in normal recirculation of lymphocytes between the blood and the tissues of the gastrointestinal tract. In this study we have examined the expression of MAdCAM‐1 in human liver. Methods: MAdCAM‐1 expression was determined in archival human liver tissues by immunohistochemistry. Results: While MAdCAM‐1 was not detected in normal fetal or adult human liver, expression was observed in association with portal tract inflammation in a variety of liver diseases. Detailed analysis of liver biopsies from patients with hepatitis C showed a positive correlation between the portal/periportal component of the histological activity index (HAI) grade and the presence or absence of MAdCAM‐1 expression. Conclusion: MAdCAM‐1 expression may be important in the recruitment of lymphocytes to the liver during inflammation.
ISSN:0106-9543
1600-0676
DOI:10.1111/j.1478-3231.1999.tb00084.x