Catalytic Asymmetric Friedel−Crafts Alkylation ReactionsCopper Showed the Way

The catalytic asymmetric alkylation reactions discovered by Charles Friedel and James Mason Crafts are discussed. The alkylation of aromatic and heteroaromatic compounds in which a hydrogen atom is replaced by an alkl group is a focus.

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Bibliographic Details
Published in:Chemical reviews 2008-08, Vol.108 (8), p.2903-2915
Main Authors: Poulsen, Thomas B, Jørgensen, Karl Anker
Format: Article
Language:English
Subjects:
4th thematic review
Alcohols - chemical synthesis
Alcohols - chemistry
Alkenes - chemistry
Alkylation
Amines - chemical synthesis
Amines - chemistry
Catalysis
Chemical compounds
Chemical reactions
Chemistry
Copper
Copper - chemistry
Hydrogen
Imines - chemistry
Ketones - chemical synthesis
Ketones - chemistry
Molecular Structure
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Stereoisomerism
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Description
Summary:The catalytic asymmetric alkylation reactions discovered by Charles Friedel and James Mason Crafts are discussed. The alkylation of aromatic and heteroaromatic compounds in which a hydrogen atom is replaced by an alkl group is a focus.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr078372e