The Increase of Parathyroid Hormone-Related Peptide and Cytokine Levels in Synovial Fluid of Elderly Rheumatoid Arthritis and Osteoarthritis

• Published in: ENDOCRINE JOURNAL 1999, Vol.46(5), pp.643-649
• Main Authors: HORIUCHI, TOSHIYUKI, YOSHIDA, TSUYOSHI, KOSHIHARA, YASUKO, SAKAMOTO, HIROSHI, KANAI, HIROYUKI, YAMAMOTO, SEIZO, ITO, HIDEKI
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid - metabolism; Cytokines; Cytokines - analysis; Cytokines - metabolism; Elderly osteoarthritis; Elderly rheumatoid arthritis; Female; Fibroblasts - chemistry; Fibroblasts - metabolism; Humans; Interleukin-1 - analysis; Interleukin-2 - analysis; Interleukin-4 - analysis; Interleukin-6 - analysis; Interleukin-8 - analysis; Knee Joint; Male; Middle Aged; Osteoarthritis - metabolism; Parathyroid hormone-related peptide; Parathyroid Hormone-Related Protein; Proteins - analysis; Proteins - metabolism; Synovial fibroblast; Synovial Fluid - chemistry; Synovial Fluid - metabolism; Synovial Membrane - pathology; Tumor Necrosis Factor-alpha - analysis
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.46.643

We simultaneously measured the concentrations of parathyroid hormone related peptide (PTHrP) and cytokines in synovial fluid (SF) to clarify the relationship between PTHrP and cytokine network in the SF of elderly patients with arthritis. SF was collected from knee joints of five RA patients aged 66±11 years old and nine osteoarthritis (OA) patients aged 80±9 years old. PTHrP in SF was measured by enzyme-linked immunosorbent assay (ELISA), whereas tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6) and interleukin-8 (IL-8) in SF were all measured by ELISA. The PTHrP levels in the SF of RA patients (2.56±0.89pmol/l) were significantly (p