Synthesis and anticonvulsant activity of some (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones

Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the mos...

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Bibliographic Details
Published in:Farmaco (Società chimica italiana : 1989) 1999-11, Vol.54 (11), p.842-845
Main Authors: Çakir, Bilge, Yildirim, Engin, Ercanli, Taner, Erol, Kevser, Sahin, M.Fethi
Format: Article
Language:English
Subjects:
Acetohydrazones
Animals
Anticonvulsant activity
Anticonvulsants - chemical synthesis
Anticonvulsants - chemistry
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Benzaldehydes - chemical synthesis
Benzaldehydes - chemistry
Benzaldehydes - pharmacology
Biological and medical sciences
Magnetic Resonance Spectroscopy
Male
Medical sciences
Mice
Molecular Structure
Neuropharmacology
Pentylenetetrazole
Pharmacology. Drug treatments
Spectrophotometry, Infrared
Thiazoles - chemical synthesis
Thiazoles - chemistry
Thiazoles - pharmacology
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Summary:Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the most promising among the others.
ISSN:0014-827X
1879-0569
DOI:10.1016/S0014-827X(99)00110-X