In vivo detection and staging of epithelial dysplasias and malignancies based on the quantitative assessment of acetic acid–tissue interaction kinetics

A novel approach to the problem of non-destructive detection and staging of tissue lesions is presented. The method relies on the in vivo quantitative assessment of the spatial and temporal alterations of light-scattering properties, induced in epithelial dysplasias and malignancies of the cervix an...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 1999-11, Vol.53 (1), p.153-157
Main Authors: Balas, Costas J, Themelis, George C, Prokopakis, Emmanuel P, Orfanudaki, Irene, Koumantakis, Eugenios, Helidonis, Emmanuel S
Format: Article
Language:English
Subjects:
Acetic Acid - administration & dosage
Administration, Topical
Cancer
Cervix
Female
Humans
Imaging
Kinetics
Laryngeal Neoplasms - diagnosis
Laryngeal Neoplasms - pathology
Larynx
Optical biopsy
Sensitivity and Specificity
Spectroscopy
Uterine Cervical Dysplasia - diagnosis
Uterine Cervical Dysplasia - pathology
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - pathology
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Summary:A novel approach to the problem of non-destructive detection and staging of tissue lesions is presented. The method relies on the in vivo quantitative assessment of the spatial and temporal alterations of light-scattering properties, induced in epithelial dysplasias and malignancies of the cervix and larynx, after topical application of acetic acid solution. Initial clinical trials show that the method is capable of detecting incipient lesions and that differences in the dysplasia and malignancy grade are clearly manifested in the measured temporal characteristics of the phenomenon.
ISSN:1011-1344
1873-2682
DOI:10.1016/S1011-1344(99)00133-5