Effect of early initiation of highly active antiretroviral therapy on CD4 cell count and HIV‐RNA viral load trends within 24 months of the onset of acute retroviral syndrome

Objectives The effect of starting highly active antiretroviral therapy (HAART) early after the onset of acute retroviral syndrome (ARS) on CD4 and HIV‐RNA trends was studied over a 2‐year follow‐up period. Methods Four groups of HIV‐infected patients stratified according to the time interval from AR...

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Bibliographic Details
Published in:HIV medicine 2008-07, Vol.9 (6), p.440-444
Main Authors: Voirin, N, Routy, J‐P, Smith, D, Baratin, D, Trépo, C, Cotte, L, Touraine, J‐L, Livrozet, J‐M, Cooper, DA, Ritter, J, André, P, Vanhems, P
Format: Article
Language:English
Subjects:
acute disease
Adult
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - drug effects
Disease Progression
Female
highly active antiretroviral therapy
HIV infections
HIV Infections - drug therapy
HIV-1
Human immunodeficiency virus
Humans
Male
RNA, Viral
Time Factors
Viral Load
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Summary:Objectives The effect of starting highly active antiretroviral therapy (HAART) early after the onset of acute retroviral syndrome (ARS) on CD4 and HIV‐RNA trends was studied over a 2‐year follow‐up period. Methods Four groups of HIV‐infected patients stratified according to the time interval from ARS onset to HAART initiation and a control group of untreated patients were compared. Results The results indicated that the earlier the start of HAART, the faster was the rate of CD4 increase and HIV‐RNA decrease. However, this difference did not seem to persist at 24 months. Conclusions The optimal treatment strategy for HIV‐infected patients needs to be explored further.
ISSN:1464-2662
1468-1293
DOI:10.1111/j.1468-1293.2008.00576.x