birth of therapy with cultured cells

Long ago, I set out to solve a problem, but something happened along the way: I was diverted by an unexpected observation. Thereafter, the direction of my research was guided at each stage by increasing familiarity with the experimental material and what could be done with it. The result was the bir...

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Bibliographic Details
Published in:BioEssays 2008-09, Vol.30 (9), p.897-903
Main Author: Green, Howard
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Cell Culture Techniques - history
Cell Line
Cell Transplantation - history
Cells, Cultured
Coculture Techniques
Epidermis - anatomy & histology
Epidermis - pathology
Epidermis - physiology
History, 20th Century
History, 21st Century
Humans
Keratinocytes - cytology
Keratinocytes - physiology
Keratinocytes - transplantation
Mice
Stem Cells - cytology
Stem Cells - physiology
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Summary:Long ago, I set out to solve a problem, but something happened along the way: I was diverted by an unexpected observation. Thereafter, the direction of my research was guided at each stage by increasing familiarity with the experimental material and what could be done with it. The result was the birth of therapy with cultured keratinocytes. Subsequent developments soon led to the formation of the company Biosurface Technology (later taken over by the Genzyme Corporation), which provided autologous cultures for burn victims in many parts of the world. Further progress by others led to new therapeutic applications of cultured keratinocytes, such as treatment of an ocular disease and gene therapy. Unfortunately, there have developed serious regulatory problems that are a danger to future progress. As described in this brief history, the initial stages of development of cell therapy for the treatment of human disease were possible only because there was no restraint by committees or governmental regulations. BioEssays 30:897-903, 2008.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.20797