A Novel Signaling Molecule for Neuropeptide Action: Activity-dependent Neuroprotective Protein

: The complete coding sequence of a novel protein (828 amino acids, pI 5.99), a potential new mediator of vasoactive intestinal peptide (VIP) activity was recently revealed. The expression of this molecule, activity‐dependent neuroprotective protein (ADNP), was augmented in the presence of VIP, in c...

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Published in:Annals of the New York Academy of Sciences 1999-12, Vol.897 (1), p.125-135
Main Authors: GOZES, ILLANA, BASSAN, MERAV, ZAMOSTIANO, RACHEL, PINHASOV, ALBERT, DAVIDSON, ARIANE, GILADI, ELIEZER, PERL, ORLY, GLAZNER, GORDON W., BRENNEMAN, DOUGLAS E.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Brain - physiology
Humans
Mice
Molecular Sequence Data
Nerve Tissue Proteins - chemistry
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Neuropeptides - physiology
Neuroprotective Agents
Oligopeptides
Signal Transduction - physiology
Transcription, Genetic
Vasoactive Intestinal Peptide - physiology
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Summary:: The complete coding sequence of a novel protein (828 amino acids, pI 5.99), a potential new mediator of vasoactive intestinal peptide (VIP) activity was recently revealed. The expression of this molecule, activity‐dependent neuroprotective protein (ADNP), was augmented in the presence of VIP, in cerebral cortical astrocytes. The mRNA transcripts encoding ADNP were enriched in the mouse hippocampus and cerebellum. The protein deduced sequence contained the following: (1) a unique peptide, NAPVSIPQ, sharing structural and immunological homologies with the previously reported, activity‐dependent neurotrophic factor (ADNF) and exhibiting neuroprotection in vitro and in vivo; (2) a glutaredoxin active site; and (3) a classical zinc binding domain. Comparative studies suggested that the peptide, NAPVSIPQ (NAP), was more efficacious than peptides derived from ADNF. ADNP, a potential mediator of VIP‐associated neuronal survival, and the new peptide, a potential lead compound for drug design, are discussed below.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1999.tb07884.x