The significance of testicular reactive oxygen species on testicular histology in infertile patients

This study was designed to investigate the relationship between the effects of testicular reactive oxygen species (ROS) levels and testicular histology on infertile patients with the aid of xanthine oxidase system and testicular tissue malondialdehyde levels. Forty patients with idiopathic infertili...

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Bibliographic Details
Published in:International urology and nephrology 1999, Vol.31 (3), p.395-399
Main Authors: Yaman, Soygür, T, Yilmaz, E, Elgün, S, Keskineğe, A, Göğüş, O
Format: Article
Language:English
Subjects:
Adult
Biopsy
Humans
Infertility, Male - pathology
Male
Malondialdehyde - analysis
Reactive Oxygen Species - metabolism
Spectrophotometry
Spermatogenesis
Testis - chemistry
Testis - pathology
Thiobarbiturates - analysis
Xanthine Oxidase - analysis
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Summary:This study was designed to investigate the relationship between the effects of testicular reactive oxygen species (ROS) levels and testicular histology on infertile patients with the aid of xanthine oxidase system and testicular tissue malondialdehyde levels. Forty patients with idiopathic infertility constituted our study group. Bilateral testicular biopsies were performed and spermatogenesis was assessed histopathologically. Patients were divided into 4 groups according to spermatogenic pattern (normal spermatogenesis; hypospermatogenesis; maturation arrest; Sertoli cell only syndrome). Testicular tissue xanthine oxidase and malondialdehyde (MDA) concentrations were analyzed in each sample by spectrophotometric assay and thiobarbituric acid reaction assay, respectively. Testicular tissue MDA and xanthine oxidase concentrations were not statistically different in patients having normal spermatogenesis, with respect to Sertoli cell only syndrome, maturation arrest and hypospermatogenesis, respectively. As a result of our study we think that there are still some factors other than ROS which may be important contributors to spermatogenetic injury that need to be examined.
ISSN:0301-1623
1573-2584
DOI:10.1023/A:1007138522517