Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors

Background and Aims:  Hepatic steatosis is commonly seen in chronic hepatitis C (CHC) patients. It has been reported to be associated with both metabolic factors and viral factors, and affects the severity of fibrosis in CHC. However, the relationship between hepatic steatosis and chronic hepatitis...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2008-07, Vol.23 (7pt1), p.1082-1088
Main Authors: Peng, Dandan, Han, Ying, Ding, Huiguo, Wei, Lai
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Alanine Transaminase - blood
Biological and medical sciences
Body Mass Index
China
DNA, Viral - blood
Fatty Liver - etiology
Fatty Liver - metabolism
Fatty Liver - pathology
Fatty Liver - virology
Female
fibrosis
Fibrosis - etiology
Fibrosis - metabolism
Fibrosis - pathology
Fibrosis - virology
Gastroenterology. Liver. Pancreas. Abdomen
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - metabolism
Hepatitis B, Chronic - pathology
Human viral diseases
Humans
Infectious diseases
Liver - enzymology
Liver - pathology
Liver - virology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
necroinflammation
Odds Ratio
Other diseases. Semiology
Retrospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
steatosis
Viral diseases
Viral hepatitis
Viral Load
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Summary:Background and Aims:  Hepatic steatosis is commonly seen in chronic hepatitis C (CHC) patients. It has been reported to be associated with both metabolic factors and viral factors, and affects the severity of fibrosis in CHC. However, the relationship between hepatic steatosis and chronic hepatitis B (CHB) is unclear. The aims of this study were to investigate the frequency of hepatic steatosis in CHB patients, to identify the factors associated with its presence, and assess the relationship between the stage of steatosis and the severity of fibrosis. Methods:  Medical records of 153 adult patients with CHB who had undergone a liver biopsy within the past 4 years were included in the study. Results:  Body mass index (BMI) and age of CHB patients with steatosis was significantly higher than the patients without steatosis (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2008.05478.x