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Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors
Background and Aims: Hepatic steatosis is commonly seen in chronic hepatitis C (CHC) patients. It has been reported to be associated with both metabolic factors and viral factors, and affects the severity of fibrosis in CHC. However, the relationship between hepatic steatosis and chronic hepatitis...
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| Published in: | Journal of gastroenterology and hepatology 2008-07, Vol.23 (7pt1), p.1082-1088 |
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| container_issue | 7pt1 |
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| container_title | Journal of gastroenterology and hepatology |
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| creator | Peng, Dandan Han, Ying Ding, Huiguo Wei, Lai |
| description | Background and Aims: Hepatic steatosis is commonly seen in chronic hepatitis C (CHC) patients. It has been reported to be associated with both metabolic factors and viral factors, and affects the severity of fibrosis in CHC. However, the relationship between hepatic steatosis and chronic hepatitis B (CHB) is unclear. The aims of this study were to investigate the frequency of hepatic steatosis in CHB patients, to identify the factors associated with its presence, and assess the relationship between the stage of steatosis and the severity of fibrosis.
Methods: Medical records of 153 adult patients with CHB who had undergone a liver biopsy within the past 4 years were included in the study.
Results: Body mass index (BMI) and age of CHB patients with steatosis was significantly higher than the patients without steatosis (P |
| doi_str_mv | 10.1111/j.1440-1746.2008.05478.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69436810</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20922738</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4668-c25165be03074d48c9c004be04323c39890a644393e5a0a9c43f88c258264ce83</originalsourceid><addsrcrecordid>eNqNkU1vEzEQhi1ERUPhLyBf4Lbb8deufeAAVZs0qgoHvm6W43gVh_1IbadN_z3eJg1H8MXjmfcZj-ZFCBMoST7n65JwDgWpeVVSAFmC4LUsdy_Q5Fh4iSYgiSgUI-oUvY5xDQAcavEKnRJZ50CpCepnbmOStzgmZ9IQfcS-x3YVhj4nV0_FlJOf8Ri5PuV6xCbGwXqT3BI_-LTCnUtmMbSZaIxNQ4i4G4LDaWV6fO-DaZ_zb9BJY9ro3h7uM_T96vLbxay4-TK9vvh0U1heVbKwVJBKLBwwqPmSS6tsnj2_OaPMMiUVmIpzppgTBoyynDVSZkrSilsn2Rn6sO-7CcPd1sWkOx-ta1vTu2EbdaU4qySBfwopKEprNnaUe6ENQ4zBNXoTfGfCoyagR1P0Wo-71-Pu9WiKfjJF7zL67vDHdtG55V_w4EIWvD8ITLSmbYLprY9HHQUBgnKRdR_3ugffusf_HkDPp7Mxynyx5312e3fkTfitq5rVQv-8ner51Y9f5HY611_ZH3B1txw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20922738</pqid></control><display><type>article</type><title>Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors</title><source>Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list)</source><creator>Peng, Dandan ; Han, Ying ; Ding, Huiguo ; Wei, Lai</creator><creatorcontrib>Peng, Dandan ; Han, Ying ; Ding, Huiguo ; Wei, Lai</creatorcontrib><description>Background and Aims: Hepatic steatosis is commonly seen in chronic hepatitis C (CHC) patients. It has been reported to be associated with both metabolic factors and viral factors, and affects the severity of fibrosis in CHC. However, the relationship between hepatic steatosis and chronic hepatitis B (CHB) is unclear. The aims of this study were to investigate the frequency of hepatic steatosis in CHB patients, to identify the factors associated with its presence, and assess the relationship between the stage of steatosis and the severity of fibrosis.
Methods: Medical records of 153 adult patients with CHB who had undergone a liver biopsy within the past 4 years were included in the study.
Results: Body mass index (BMI) and age of CHB patients with steatosis was significantly higher than the patients without steatosis (P < 0.05), as determined by the univariate analysis. Steatosis was found to correlate with the BMI values and alanine aminotransferase (ALT) levels, and ALT levels were associated with hepatitis B virus (HBV)–DNA levels and histology activity index (HAI) scores, stages of fibrosis were associated with the HAI score and HBV–DNA, as determined by the multivariate analysis. In contrast, there was no significant association between advanced stages of fibrosis and steatosis.
Conclusion: Our data indicate that hepatic steatosis is more frequently present in CHB patients than in the general population. We hypothesize that steatosis in CHB patients may be due to metabolic factors and the ability of HBV to indirectly facilitate the development of steatosis. In the present study, steatosis in CHB patients was not found to be associated with the severity of fibrosis.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.2008.05478.x</identifier><identifier>PMID: 18707599</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adolescent ; Adult ; Age Factors ; Alanine Transaminase - blood ; Biological and medical sciences ; Body Mass Index ; China ; DNA, Viral - blood ; Fatty Liver - etiology ; Fatty Liver - metabolism ; Fatty Liver - pathology ; Fatty Liver - virology ; Female ; fibrosis ; Fibrosis - etiology ; Fibrosis - metabolism ; Fibrosis - pathology ; Fibrosis - virology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B, Chronic - complications ; Hepatitis B, Chronic - metabolism ; Hepatitis B, Chronic - pathology ; Human viral diseases ; Humans ; Infectious diseases ; Liver - enzymology ; Liver - pathology ; Liver - virology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; necroinflammation ; Odds Ratio ; Other diseases. Semiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; steatosis ; Viral diseases ; Viral hepatitis ; Viral Load</subject><ispartof>Journal of gastroenterology and hepatology, 2008-07, Vol.23 (7pt1), p.1082-1088</ispartof><rights>2008 The Authors. Journal compilation © 2008 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4668-c25165be03074d48c9c004be04323c39890a644393e5a0a9c43f88c258264ce83</citedby><cites>FETCH-LOGICAL-c4668-c25165be03074d48c9c004be04323c39890a644393e5a0a9c43f88c258264ce83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20505245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18707599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Dandan</creatorcontrib><creatorcontrib>Han, Ying</creatorcontrib><creatorcontrib>Ding, Huiguo</creatorcontrib><creatorcontrib>Wei, Lai</creatorcontrib><title>Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aims: Hepatic steatosis is commonly seen in chronic hepatitis C (CHC) patients. It has been reported to be associated with both metabolic factors and viral factors, and affects the severity of fibrosis in CHC. However, the relationship between hepatic steatosis and chronic hepatitis B (CHB) is unclear. The aims of this study were to investigate the frequency of hepatic steatosis in CHB patients, to identify the factors associated with its presence, and assess the relationship between the stage of steatosis and the severity of fibrosis.
Methods: Medical records of 153 adult patients with CHB who had undergone a liver biopsy within the past 4 years were included in the study.
Results: Body mass index (BMI) and age of CHB patients with steatosis was significantly higher than the patients without steatosis (P < 0.05), as determined by the univariate analysis. Steatosis was found to correlate with the BMI values and alanine aminotransferase (ALT) levels, and ALT levels were associated with hepatitis B virus (HBV)–DNA levels and histology activity index (HAI) scores, stages of fibrosis were associated with the HAI score and HBV–DNA, as determined by the multivariate analysis. In contrast, there was no significant association between advanced stages of fibrosis and steatosis.
Conclusion: Our data indicate that hepatic steatosis is more frequently present in CHB patients than in the general population. We hypothesize that steatosis in CHB patients may be due to metabolic factors and the ability of HBV to indirectly facilitate the development of steatosis. In the present study, steatosis in CHB patients was not found to be associated with the severity of fibrosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Alanine Transaminase - blood</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>China</subject><subject>DNA, Viral - blood</subject><subject>Fatty Liver - etiology</subject><subject>Fatty Liver - metabolism</subject><subject>Fatty Liver - pathology</subject><subject>Fatty Liver - virology</subject><subject>Female</subject><subject>fibrosis</subject><subject>Fibrosis - etiology</subject><subject>Fibrosis - metabolism</subject><subject>Fibrosis - pathology</subject><subject>Fibrosis - virology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Hepatitis B, Chronic - metabolism</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver - enzymology</subject><subject>Liver - pathology</subject><subject>Liver - virology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>necroinflammation</subject><subject>Odds Ratio</subject><subject>Other diseases. Semiology</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>steatosis</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viral Load</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkU1vEzEQhi1ERUPhLyBf4Lbb8deufeAAVZs0qgoHvm6W43gVh_1IbadN_z3eJg1H8MXjmfcZj-ZFCBMoST7n65JwDgWpeVVSAFmC4LUsdy_Q5Fh4iSYgiSgUI-oUvY5xDQAcavEKnRJZ50CpCepnbmOStzgmZ9IQfcS-x3YVhj4nV0_FlJOf8Ri5PuV6xCbGwXqT3BI_-LTCnUtmMbSZaIxNQ4i4G4LDaWV6fO-DaZ_zb9BJY9ro3h7uM_T96vLbxay4-TK9vvh0U1heVbKwVJBKLBwwqPmSS6tsnj2_OaPMMiUVmIpzppgTBoyynDVSZkrSilsn2Rn6sO-7CcPd1sWkOx-ta1vTu2EbdaU4qySBfwopKEprNnaUe6ENQ4zBNXoTfGfCoyagR1P0Wo-71-Pu9WiKfjJF7zL67vDHdtG55V_w4EIWvD8ITLSmbYLprY9HHQUBgnKRdR_3ugffusf_HkDPp7Mxynyx5312e3fkTfitq5rVQv-8ner51Y9f5HY611_ZH3B1txw</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Peng, Dandan</creator><creator>Han, Ying</creator><creator>Ding, Huiguo</creator><creator>Wei, Lai</creator><general>Blackwell Publishing Asia</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors</title><author>Peng, Dandan ; Han, Ying ; Ding, Huiguo ; Wei, Lai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4668-c25165be03074d48c9c004be04323c39890a644393e5a0a9c43f88c258264ce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Alanine Transaminase - blood</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>China</topic><topic>DNA, Viral - blood</topic><topic>Fatty Liver - etiology</topic><topic>Fatty Liver - metabolism</topic><topic>Fatty Liver - pathology</topic><topic>Fatty Liver - virology</topic><topic>Female</topic><topic>fibrosis</topic><topic>Fibrosis - etiology</topic><topic>Fibrosis - metabolism</topic><topic>Fibrosis - pathology</topic><topic>Fibrosis - virology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Hepatitis B, Chronic - metabolism</topic><topic>Hepatitis B, Chronic - pathology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver - enzymology</topic><topic>Liver - pathology</topic><topic>Liver - virology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>necroinflammation</topic><topic>Odds Ratio</topic><topic>Other diseases. Semiology</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>steatosis</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Dandan</creatorcontrib><creatorcontrib>Han, Ying</creatorcontrib><creatorcontrib>Ding, Huiguo</creatorcontrib><creatorcontrib>Wei, Lai</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Dandan</au><au>Han, Ying</au><au>Ding, Huiguo</au><au>Wei, Lai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>23</volume><issue>7pt1</issue><spage>1082</spage><epage>1088</epage><pages>1082-1088</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aims: Hepatic steatosis is commonly seen in chronic hepatitis C (CHC) patients. It has been reported to be associated with both metabolic factors and viral factors, and affects the severity of fibrosis in CHC. However, the relationship between hepatic steatosis and chronic hepatitis B (CHB) is unclear. The aims of this study were to investigate the frequency of hepatic steatosis in CHB patients, to identify the factors associated with its presence, and assess the relationship between the stage of steatosis and the severity of fibrosis.
Methods: Medical records of 153 adult patients with CHB who had undergone a liver biopsy within the past 4 years were included in the study.
Results: Body mass index (BMI) and age of CHB patients with steatosis was significantly higher than the patients without steatosis (P < 0.05), as determined by the univariate analysis. Steatosis was found to correlate with the BMI values and alanine aminotransferase (ALT) levels, and ALT levels were associated with hepatitis B virus (HBV)–DNA levels and histology activity index (HAI) scores, stages of fibrosis were associated with the HAI score and HBV–DNA, as determined by the multivariate analysis. In contrast, there was no significant association between advanced stages of fibrosis and steatosis.
Conclusion: Our data indicate that hepatic steatosis is more frequently present in CHB patients than in the general population. We hypothesize that steatosis in CHB patients may be due to metabolic factors and the ability of HBV to indirectly facilitate the development of steatosis. In the present study, steatosis in CHB patients was not found to be associated with the severity of fibrosis.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>18707599</pmid><doi>10.1111/j.1440-1746.2008.05478.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Alanine Transaminase - blood Biological and medical sciences Body Mass Index China DNA, Viral - blood Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - pathology Fatty Liver - virology Female fibrosis Fibrosis - etiology Fibrosis - metabolism Fibrosis - pathology Fibrosis - virology Gastroenterology. Liver. Pancreas. Abdomen Hepatitis B virus Hepatitis B virus - genetics Hepatitis B, Chronic - complications Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - pathology Human viral diseases Humans Infectious diseases Liver - enzymology Liver - pathology Liver - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged necroinflammation Odds Ratio Other diseases. Semiology Retrospective Studies Risk Assessment Risk Factors Severity of Illness Index steatosis Viral diseases Viral hepatitis Viral Load |
| title | Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors |
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