Viral diversity and dynamics in an infant gut

Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral s...

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Bibliographic Details
Published in:Research in microbiology 2008-06, Vol.159 (5), p.367-373
Main Authors: Breitbart, Mya, Haynes, Matthew, Kelley, Scott, Angly, Florent, Edwards, Robert A., Felts, Ben, Mahaffy, Joseph M., Mueller, Jennifer, Nulton, James, Rayhawk, Steve, Rodriguez-Brito, Beltran, Salamon, Peter, Rohwer, Forest
Format: Article
Language:English
Subjects:
Biodiversity
Biological and medical sciences
DNA Viruses - classification
DNA Viruses - genetics
DNA Viruses - isolation & purification
DNA Viruses - ultrastructure
DNA, Viral - genetics
Feces
Feces - virology
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - virology
Gut
Humans
Infant
Infant Food - analysis
Male
Metagenomics
Microarray
Microbiology
Miscellaneous
Molecular Sequence Data
Oligonucleotide Array Sequence Analysis
Phage
Virology
Virus
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Summary:Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.
ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2008.04.006