Complex temporal patterns of spontaneous initiation and termination of reentry in a loop of cardiac tissue

A two-component model is developed consisting of a discrete loop of cardiac cells that circulates action potentials as well as a pacing mechanism. Physiological properties of cells such as restitutions of refractoriness and of conduction velocity are given via experimentally measured functions. The...

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Bibliographic Details
Published in:Journal of theoretical biology 2008-09, Vol.254 (1), p.14-26
Main Authors: Sedaghat, H., Wood, M.A., Cain, J.W., Cheng, C.K., Baumgarten, C.M., Chan, D.M.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Bistability
Computer Simulation
Electrocardiography
Heart Block - physiopathology
Heart Conduction System - physiology
Humans
Loop
Models, Cardiovascular
Myocardial Contraction - physiology
Pacer
Reentry
Tachycardia - physiopathology
Thresholds
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Summary:A two-component model is developed consisting of a discrete loop of cardiac cells that circulates action potentials as well as a pacing mechanism. Physiological properties of cells such as restitutions of refractoriness and of conduction velocity are given via experimentally measured functions. The dynamics of circulating pulses and the pacer's action are regulated by two threshold relations. Patterns of spontaneous initiations and terminations of reentry (SITR) generated by this system are studied through numerical simulations and analytical observations. These patterns can be regular or irregular; causes of irregularities are identified as the threshold bistability (T-bistability) of reentrant circulation and in some cases, also phase-resetting interactions with the pacer.
ISSN:0022-5193
1095-8541
DOI:10.1016/j.jtbi.2008.05.003