Is there a local renin-angiotensin system in the heart?

The existence of a local renin-angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production...

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Bibliographic Details
Published in:Cardiovascular research 1999-11, Vol.44 (2), p.252-265
Main Authors: DANSER, A. H. J, SARIS, J. J, SCHUIJT, M. P, VAN KATS, J. P
Format: Article
Language:English
Subjects:
Angiotensin I - metabolism
Angiotensin II - metabolism
Angiotensinogen - metabolism
Biological and medical sciences
Cell Membrane - metabolism
Cells, Cultured
Fundamental and applied biological sciences. Psychology
Heart
Humans
Intracellular Fluid - metabolism
Mannosephosphates - metabolism
Myocardium - metabolism
Peptidyl-Dipeptidase A - metabolism
Perfusion
Renin - metabolism
Renin-Angiotensin System - physiology
Vertebrates: cardiovascular system
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Summary:The existence of a local renin-angiotensin system in the heart is still a controversial issue. This review discusses the evidence, obtained from studies in cardiac cells, in isolated perfused hearts and in intact animals and humans, both under normal and pathological conditions, for local production of prorenin, renin, angiotensinogen, angiotensin-converting enzyme, angiotensin I and angiotensin II at cardiac tissue sites. In addition, the role of alternative angiotensin-generating enzymes (cathepsin, chymase) and the possibility of (pro)renin uptake from the circulation is evaluated.
ISSN:0008-6363
1755-3245
DOI:10.1016/S0008-6363(99)00202-3