Prognostic significance of proliferative and apoptotic markers in oral tongue squamous cell carcinomas

The prognostic impact of proliferative and apoptotic markers was studied in 85 T1-4 oral tongue squamous cell carcinomas (SCCs). Ki67 immunoreactivity and AgNOR counts, including mean AgNOR counts (mAgNOR) and the percentage of nuclei with more than one AgNOR (pAgNOR>1), were used as proliferativ...

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Bibliographic Details
Published in:Oral oncology 1999-09, Vol.35 (5), p.502-509
Main Authors: Xie, Xin, De Angelis, P., Clausen, O.P.F., Boysen, M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
AgNOR
Apoptosis
Apoptosis - physiology
Bax
bcl-2-Associated X Protein
Biological and medical sciences
Biomarkers, Tumor - analysis
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - physiopathology
Cell Division
Disease-Free Survival
Diterpenes - metabolism
Female
Humans
Ki-67 Antigen - analysis
Ki67
Male
Medical sciences
Middle Aged
Otorhinolaryngology. Stomatology
Prognosis
Proliferation
Proto-Oncogene Proteins - metabolism
Proto-Oncogene Proteins c-bcl-2
Spontaneous apoptosis
Staining and Labeling - methods
Tongue Neoplasms - pathology
Tongue Neoplasms - physiopathology
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:The prognostic impact of proliferative and apoptotic markers was studied in 85 T1-4 oral tongue squamous cell carcinomas (SCCs). Ki67 immunoreactivity and AgNOR counts, including mean AgNOR counts (mAgNOR) and the percentage of nuclei with more than one AgNOR (pAgNOR>1), were used as proliferative parameters. The apoptotic index (AI) was assessed using the TUNEL method. Bax expression was detected immunohistochemically and scored. Bax expression correlated positively with AI ( p=0.0122). Ki67 correlated with both pAgNOR>1 ( p=0.0042) and mAgNOR ( p=0.0189). Low Bax expression and low AI correlated significantly with the disease-free period ( p=0.0001 and p=0.0024, respectively). High values for Ki67, pAgNOR>1 and mAgNOR correlated with poor prognosis ( p=0.0021, p=0.0001 and p=0.0244, respectively). Combinations of proliferative and apoptotic parameters were stronger predictors than individual parameters ( p1–Bax expression appeared to be the best combination ( p
ISSN:1368-8375
1879-0593
DOI:10.1016/S1368-8375(99)00024-X