MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination

Characterization of regulatory mechanisms affecting microRNA (miRNA) expression and activity is providing novel clues for the identification of genes and complex regulatory circuits that determine cell and tissue specificity. Here, we review the molecular events leading to miRNA biogenesis and activ...

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Bibliographic Details
Published in:Cardiovascular research 2008-09, Vol.79 (4), p.553-561
Main Authors: Fazi, Francesco, Nervi, Clara
Format: Article
Language:English
Subjects:
Animals
Cell differentiation
Cell Differentiation - genetics
Cell Lineage - genetics
Epigenesis, Genetic
Epigenetic gene regulation
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Hematopoiesis - genetics
Humans
MicroRNAs
MicroRNAs - metabolism
Muscle Development - genetics
Muscle, Skeletal - metabolism
Myocardium - metabolism
Nerve Tissue - metabolism
Transcription factors
Transcription, Genetic
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Summary:Characterization of regulatory mechanisms affecting microRNA (miRNA) expression and activity is providing novel clues for the identification of genes and complex regulatory circuits that determine cell and tissue specificity. Here, we review the molecular events leading to miRNA biogenesis and activity, focusing above all on endogenous and epigenetic transcriptional networks involving miRNA in early development, cellular lineage specification/differentiation of nervous, skeletal and cardiac muscle tissues and in haematopoiesis, as the de-regulation of such networks may be relevant to disease pathogenesis.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvn151