Quantification of right ventricular function in acute pulmonary embolism: relation to extent of pulmonary perfusion defects

Aims The relation of the extent of obstruction of the pulmonary vasculature in pulmonary embolism (PE) and impact on right ventricular (RV) hemodynamics is not well established. This study evaluated the relation of size of perfusion defects and changes in echocardiographic measures of global and reg...

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Bibliographic Details
Published in:European journal of echocardiography 2008-09, Vol.9 (5), p.641-645
Main Authors: Kjaergaard, Jesper, Schaadt, Bente Krogsgaard, Lund, Jens Otto, Hassager, Christian
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Case-Control Studies
Female
Humans
Male
Middle Aged
Pulmonary Artery - diagnostic imaging
Pulmonary Artery - physiopathology
Pulmonary Circulation
Pulmonary Embolism - diagnostic imaging
Pulmonary Embolism - physiopathology
Stroke Volume
Ultrasonography
Ventricular Dysfunction, Right - diagnostic imaging
Ventricular Dysfunction, Right - physiopathology
Ventricular Function, Left
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Summary:Aims The relation of the extent of obstruction of the pulmonary vasculature in pulmonary embolism (PE) and impact on right ventricular (RV) hemodynamics is not well established. This study evaluated the relation of size of perfusion defects and changes in echocardiographic measures of global and regional RV dysfunction in 58 consecutive patients with non-massive PE. Methods and results Patients were compared with 58 age-matched controls that had normal ventilation/perfusion scintigraphies. A 2D, Doppler and Tissue Doppler echocardiography performed on the same day, quantified RV pressure and global and regional performance. Intermediate and large pulmonary emboli were associated with a significant impact on RV pressure and function. For small pulmonary emboli obstructing
ISSN:1525-2167
1532-2114
DOI:10.1093/ejechocard/jen033