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A Meta-Analysis on the Efficacy of Probiotics for Maintenance of Remission and Prevention of Clinical and Endoscopic Relapse in Crohn’s Disease
Objective To evaluate whether probiotics maintain remission in patients with Crohn’s disease (CD). Design A meta-analysis of controlled clinical trials. Methods PUBMED and Cochrane Central Register of Controlled Trials were searched for clinical trial studies investigated the efficacy of probiotics...
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| Published in: | Digestive diseases and sciences 2008-09, Vol.53 (9), p.2524-2531 |
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| container_end_page | 2531 |
| container_issue | 9 |
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| container_title | Digestive diseases and sciences |
| container_volume | 53 |
| creator | Rahimi, Roja Nikfar, Shekoufeh Rahimi, Fatemeh Elahi, Behzad Derakhshani, Saeed Vafaie, Mohammad Abdollahi, Mohammad |
| description | Objective
To evaluate whether probiotics maintain remission in patients with Crohn’s disease (CD).
Design
A meta-analysis of controlled clinical trials.
Methods
PUBMED and Cochrane Central Register of Controlled Trials were searched for clinical trial studies investigated the efficacy of probiotics for the maintenance of remission in Crohn’s disease. Clinical relapse and endoscopic relapse were the key outcomes of interest. Data were searched within the time period of 1966 through may 2007.
Result
Eight randomized placebo-controlled clinical trials met our criteria and were included in the analysis. Seven determined clinical relapse and three evaluated endoscopic relapse among patients with CD received probiotics for maintenance of remission. Pooling of seven trials for the outcome of clinical relapse yielded an odds ratio of 0.92 (95% confidence interval of 0.52–1.62,
P
= 0.8853), a nonsignificant odds ratio. The odds ratio for three studies for the outcome of endoscopic relapse was 0.97 (95% confidence interval of 0.54–1.78,
P
= 0.93), a nonsignificant odds ratio.
Conclusion
This meta-analysis fails to demonstrate the efficacy of probiotics in maintaining remission and preventing clinical and endoscopic recurrence in CD. It is suggested to use probiotic preparations containing a mixture of lactobacillus with
E. coli
or
Saccharomyces
. |
| doi_str_mv | 10.1007/s10620-007-0171-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69448026</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1537749971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c496t-21f5a3ee93d4d3da6a18d84335d33e7f66810a4f06668ee3299a2e8ee61fe6303</originalsourceid><addsrcrecordid>eNqFkc-KFDEQxoMo7uzqA3iRILi31qqkO919HMbxD-yiiJ6bbHfFzdKTjKkeYW6-gkdfzycxvTO4IIinfOH7VaUqnxBPEF4gQP2SEYyCIssCsMYC7okFVrUuVGWa-2IBaLJGNCfilPkGANoazUNxgo2qodFmIX4s5SVNtlgGO-7Zs4xBTtck18753vZ7GZ38kOKVj5PvWbqY5KX1YaJgQ0-z-5E2ntnnOhuGzNI3CtN8zd5q9CG3GW-tdRgi93Hr-1wz2i2T9EGuUrwOv77_ZPnKM1mmR-KBsyPT4-N5Jj6_Xn9avS0u3r95t1peFH3Zmimv5SqriVo9lIMerLHYDE2pdTVoTbUzpkGwpQOTFZFWbWsVZWXQkdGgz8T5oe82xa874qnLe_Q0jjZQ3HFn2rJsQJn_gti2gLpWGXz2F3gTdyl_LHcKS60a1G2G8AD1KTInct02-Y1N-w6hm1PtDql2s5xT7eZRnx4b7642NNxVHGPMwPMjYDl_t0s5HM9_OAWmMni7szpwnK3whdLdhP9-_Tct97pU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214328139</pqid></control><display><type>article</type><title>A Meta-Analysis on the Efficacy of Probiotics for Maintenance of Remission and Prevention of Clinical and Endoscopic Relapse in Crohn’s Disease</title><source>Springer Link</source><creator>Rahimi, Roja ; Nikfar, Shekoufeh ; Rahimi, Fatemeh ; Elahi, Behzad ; Derakhshani, Saeed ; Vafaie, Mohammad ; Abdollahi, Mohammad</creator><creatorcontrib>Rahimi, Roja ; Nikfar, Shekoufeh ; Rahimi, Fatemeh ; Elahi, Behzad ; Derakhshani, Saeed ; Vafaie, Mohammad ; Abdollahi, Mohammad</creatorcontrib><description>Objective
To evaluate whether probiotics maintain remission in patients with Crohn’s disease (CD).
Design
A meta-analysis of controlled clinical trials.
Methods
PUBMED and Cochrane Central Register of Controlled Trials were searched for clinical trial studies investigated the efficacy of probiotics for the maintenance of remission in Crohn’s disease. Clinical relapse and endoscopic relapse were the key outcomes of interest. Data were searched within the time period of 1966 through may 2007.
Result
Eight randomized placebo-controlled clinical trials met our criteria and were included in the analysis. Seven determined clinical relapse and three evaluated endoscopic relapse among patients with CD received probiotics for maintenance of remission. Pooling of seven trials for the outcome of clinical relapse yielded an odds ratio of 0.92 (95% confidence interval of 0.52–1.62,
P
= 0.8853), a nonsignificant odds ratio. The odds ratio for three studies for the outcome of endoscopic relapse was 0.97 (95% confidence interval of 0.54–1.78,
P
= 0.93), a nonsignificant odds ratio.
Conclusion
This meta-analysis fails to demonstrate the efficacy of probiotics in maintaining remission and preventing clinical and endoscopic recurrence in CD. It is suggested to use probiotic preparations containing a mixture of lactobacillus with
E. coli
or
Saccharomyces
.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-007-0171-0</identifier><identifier>PMID: 18270836</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biochemistry ; Biological and medical sciences ; Crohn Disease - diagnosis ; Crohn Disease - prevention & control ; Escherichia coli ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatology ; Humans ; Lactobacillus ; Medical sciences ; Medicine ; Medicine & Public Health ; Oncology ; Original Paper ; Other diseases. Semiology ; Probiotics ; Probiotics - therapeutic use ; Randomized Controlled Trials as Topic ; Remission Induction ; Saccharomyces ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Thoracoscopy ; Transplant Surgery ; Treatment Outcome ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2008-09, Vol.53 (9), p.2524-2531</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-21f5a3ee93d4d3da6a18d84335d33e7f66810a4f06668ee3299a2e8ee61fe6303</citedby><cites>FETCH-LOGICAL-c496t-21f5a3ee93d4d3da6a18d84335d33e7f66810a4f06668ee3299a2e8ee61fe6303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20656130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18270836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahimi, Roja</creatorcontrib><creatorcontrib>Nikfar, Shekoufeh</creatorcontrib><creatorcontrib>Rahimi, Fatemeh</creatorcontrib><creatorcontrib>Elahi, Behzad</creatorcontrib><creatorcontrib>Derakhshani, Saeed</creatorcontrib><creatorcontrib>Vafaie, Mohammad</creatorcontrib><creatorcontrib>Abdollahi, Mohammad</creatorcontrib><title>A Meta-Analysis on the Efficacy of Probiotics for Maintenance of Remission and Prevention of Clinical and Endoscopic Relapse in Crohn’s Disease</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Objective
To evaluate whether probiotics maintain remission in patients with Crohn’s disease (CD).
Design
A meta-analysis of controlled clinical trials.
Methods
PUBMED and Cochrane Central Register of Controlled Trials were searched for clinical trial studies investigated the efficacy of probiotics for the maintenance of remission in Crohn’s disease. Clinical relapse and endoscopic relapse were the key outcomes of interest. Data were searched within the time period of 1966 through may 2007.
Result
Eight randomized placebo-controlled clinical trials met our criteria and were included in the analysis. Seven determined clinical relapse and three evaluated endoscopic relapse among patients with CD received probiotics for maintenance of remission. Pooling of seven trials for the outcome of clinical relapse yielded an odds ratio of 0.92 (95% confidence interval of 0.52–1.62,
P
= 0.8853), a nonsignificant odds ratio. The odds ratio for three studies for the outcome of endoscopic relapse was 0.97 (95% confidence interval of 0.54–1.78,
P
= 0.93), a nonsignificant odds ratio.
Conclusion
This meta-analysis fails to demonstrate the efficacy of probiotics in maintaining remission and preventing clinical and endoscopic recurrence in CD. It is suggested to use probiotic preparations containing a mixture of lactobacillus with
E. coli
or
Saccharomyces
.</description><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Crohn Disease - diagnosis</subject><subject>Crohn Disease - prevention & control</subject><subject>Escherichia coli</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Lactobacillus</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Other diseases. Semiology</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Remission Induction</subject><subject>Saccharomyces</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Lactobacillus</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Other diseases. Semiology</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Remission Induction</topic><topic>Saccharomyces</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Thoracoscopy</topic><topic>Transplant Surgery</topic><topic>Treatment Outcome</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahimi, Roja</creatorcontrib><creatorcontrib>Nikfar, Shekoufeh</creatorcontrib><creatorcontrib>Rahimi, Fatemeh</creatorcontrib><creatorcontrib>Elahi, Behzad</creatorcontrib><creatorcontrib>Derakhshani, Saeed</creatorcontrib><creatorcontrib>Vafaie, Mohammad</creatorcontrib><creatorcontrib>Abdollahi, Mohammad</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahimi, Roja</au><au>Nikfar, Shekoufeh</au><au>Rahimi, Fatemeh</au><au>Elahi, Behzad</au><au>Derakhshani, Saeed</au><au>Vafaie, Mohammad</au><au>Abdollahi, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Meta-Analysis on the Efficacy of Probiotics for Maintenance of Remission and Prevention of Clinical and Endoscopic Relapse in Crohn’s Disease</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>53</volume><issue>9</issue><spage>2524</spage><epage>2531</epage><pages>2524-2531</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Objective
To evaluate whether probiotics maintain remission in patients with Crohn’s disease (CD).
Design
A meta-analysis of controlled clinical trials.
Methods
PUBMED and Cochrane Central Register of Controlled Trials were searched for clinical trial studies investigated the efficacy of probiotics for the maintenance of remission in Crohn’s disease. Clinical relapse and endoscopic relapse were the key outcomes of interest. Data were searched within the time period of 1966 through may 2007.
Result
Eight randomized placebo-controlled clinical trials met our criteria and were included in the analysis. Seven determined clinical relapse and three evaluated endoscopic relapse among patients with CD received probiotics for maintenance of remission. Pooling of seven trials for the outcome of clinical relapse yielded an odds ratio of 0.92 (95% confidence interval of 0.52–1.62,
P
= 0.8853), a nonsignificant odds ratio. The odds ratio for three studies for the outcome of endoscopic relapse was 0.97 (95% confidence interval of 0.54–1.78,
P
= 0.93), a nonsignificant odds ratio.
Conclusion
This meta-analysis fails to demonstrate the efficacy of probiotics in maintaining remission and preventing clinical and endoscopic recurrence in CD. It is suggested to use probiotic preparations containing a mixture of lactobacillus with
E. coli
or
Saccharomyces
.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>18270836</pmid><doi>10.1007/s10620-007-0171-0</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2008-09, Vol.53 (9), p.2524-2531 |
| issn | 0163-2116 1573-2568 |
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| source | Springer Link |
| subjects | Biochemistry Biological and medical sciences Crohn Disease - diagnosis Crohn Disease - prevention & control Escherichia coli Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Lactobacillus Medical sciences Medicine Medicine & Public Health Oncology Original Paper Other diseases. Semiology Probiotics Probiotics - therapeutic use Randomized Controlled Trials as Topic Remission Induction Saccharomyces Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thoracoscopy Transplant Surgery Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | A Meta-Analysis on the Efficacy of Probiotics for Maintenance of Remission and Prevention of Clinical and Endoscopic Relapse in Crohn’s Disease |
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