The serum levels of the EGF-like homeotic protein dlk1 correlate with different metabolic parameters in two hormonally different children populations in Spain

Summary Background  The Dlk1 gene encodes for dlk1, a transmembrane protein belonging to the EGF‐like repeat‐containing family. Dlk1 has been shown to act as a regulator of adipogenesis. Fc‐dlk1 transgenic mice show a decrease in adipose tissue and glucose tolerance, hypertriglyceridaemia and lower...

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Published in:Clinical endocrinology (Oxford) 2008-08, Vol.69 (2), p.216-224
Main Authors: Hermida, Carmen, Garcés, Carmen, De Oya, Manuel, Cano, Beatriz, Martínez-Costa, Oscar H., Rivero, Samuel, García-Ramírez, José J., Laborda, Jorge, Aragón, Juan J.
Format: Article
Language:English
Subjects:
3T3-L1 Cells
Animals
BALB 3T3 Cells
Biological and medical sciences
Biomarkers - blood
Biomarkers - metabolism
Carbohydrate Metabolism - physiology
Child
Child Development - physiology
Endocrinopathies
Fundamental and applied biological sciences. Psychology
General aspects
Health Status Indicators
Hormones - analysis
Hormones - blood
Hormones - metabolism
Humans
Intercellular Signaling Peptides and Proteins - blood
Lipid Metabolism - physiology
Medical sciences
Membrane Proteins - blood
Mice
Pichia
Spain
Vertebrates: endocrinology
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Summary:Summary Background  The Dlk1 gene encodes for dlk1, a transmembrane protein belonging to the EGF‐like repeat‐containing family. Dlk1 has been shown to act as a regulator of adipogenesis. Fc‐dlk1 transgenic mice show a decrease in adipose tissue and glucose tolerance, hypertriglyceridaemia and lower insulin sensitivity. Dlk1‐deficient mice show growth retardation, increased serum lipid metabolites and develop obesity. These data advocate for a role of dlk1 in the maintenance of lipid homeostasis, and suggest that dlk1 levels may influence the development of cardiovascular disease. Aim and methods  In this study, we analysed whether dlk1 serum levels could be indicative of the different hormonal or metabolic status shown by two Spanish children populations (6–8 years‐old), Orense and Murcia. We determined dlk1 serum levels by ELISA assay, using an antibody raised against the recombinant protein, and performed a correlation analysis against measurements of several hormonal and biochemical parameters in samples from 494 subjects. Results  We found a statistically significant positive correlation between serum levels of dlk1 and those of glucose (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2008.03170.x