Importance of surgical margins in conization for cervical intraepithelial neoplasia grade III

We conducted a retrospective study on 201 conizations for CIN III done over the last 14 years. Of these, 53 (26.4%) had involvement of the margins, 114 (56.7%) had margins free of neoplasia, and 34 (16.9%) were not evaluated. Of the 53 cases with margin involvement, 28 (52.8%) had complementary surg...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 1999-11, Vol.263 (1-2), p.42-44
Main Authors: Murta, E F, Resende, A V, Souza, M A, Adad, S J, Salum, R
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - surgery
Cervix Uteri - pathology
Conization - methods
Female
Humans
Hysterectomy - methods
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Retrospective Studies
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - surgery
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Summary:We conducted a retrospective study on 201 conizations for CIN III done over the last 14 years. Of these, 53 (26.4%) had involvement of the margins, 114 (56.7%) had margins free of neoplasia, and 34 (16.9%) were not evaluated. Of the 53 cases with margin involvement, 28 (52.8%) had complementary surgery and 25 (47.2%) cytological follow-up. Residual CIN was identified in the surgical specimen in 15 cases (53.6%) and microinvasion was present in 2 cases (7.1%). Of the 114 patients with margins free of neoplasia in the cone, 12 had a hysterectomy during follow-up for CIN III diagnosed by cytology and biopsy. Seven of these 12 patients (58.3%) had CIN in the surgical specimen and none had microinvasive cancer.
ISSN:0932-0067
1432-0711
DOI:10.1007/s004040050260