Genetic factors involved in the pathogenesis of Parkinson's disease

Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized by a loss of nigrostriatal dopaminergic neurons. Recently, PD research has been stimulated by the identification of genes that are implicated in rare familial forms of PD. However, despite these discoveries, the prim...

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Bibliographic Details
Published in:Brain Research Reviews 2008-08, Vol.58 (2), p.354-364
Main Authors: Lee, Frank J.S, Liu, Fang
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
alpha-Synuclein - genetics
Animals
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dopamine
Dopamine - metabolism
Humans
Intracellular Signaling Peptides and Proteins - genetics
Medical sciences
Membrane Proteins - genetics
Neoplasm Proteins - genetics
Neurodegeneration
Neurology
Oncogene Proteins - genetics
Organic mental disorders. Neuropsychology
Parkinson Disease - genetics
Parkinson Disease - pathology
Parkinson's disease
Protein Deglycase DJ-1
Protein Kinases - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Transporter
Ubiquitin Thiolesterase - genetics
Ubiquitin-Protein Ligases - genetics
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Summary:Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized by a loss of nigrostriatal dopaminergic neurons. Recently, PD research has been stimulated by the identification of genes that are implicated in rare familial forms of PD. However, despite these discoveries, the primary cause of PD is still unclear. Various pathogenic mechanisms may be involved including mitochondrial dysfunction, proteasomal dysfunction/protein aggregation, oxidative damage, environmental factors and genetic disposition. Furthermore, dopamine has also been implicated in contributing to the pathogenesis of PD. This review will focus on the genes that have been identified to be associated with PD and how they may impair dopamine metabolism. Understanding the role of these PD-related genes in dopamine neurobiology may provide insight into the underpinning pathogenic mechanisms of PD.
ISSN:0165-0173
1872-6321
DOI:10.1016/j.brainresrev.2008.02.001