Capillary zone electrophoresis determination of meropenem in biological media using a high sensitivity cell

A capillary electrophoresis method with a high sensitivity cell (Z-cell) has been developed for the determination of meropenem in aqueous solution and in biological media (urine, plasma). Water samples were analysed using two calibration curves of meropenem with standard capillary and a capillary wi...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1999-09, Vol.20 (6), p.899-903
Main Authors: Mrestani, Yahya, Neubert, Reinhard, Nagel, Frank
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Capillary electrophoresis with high sensitivity cell
Electrophoresis, Capillary - methods
Female
General pharmacology
Humans
Injections, Intravenous
Medical sciences
Meropenem
Pharmacology. Drug treatments
Thienamycins - administration & dosage
Thienamycins - blood
Thienamycins - urine
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Summary:A capillary electrophoresis method with a high sensitivity cell (Z-cell) has been developed for the determination of meropenem in aqueous solution and in biological media (urine, plasma). Water samples were analysed using two calibration curves of meropenem with standard capillary and a capillary with a high sensitivity cell. In urine, the samples were only diluted in buffer and were injected without any further sample preparation. For the analysis of plasma samples, a calibration curve was utilized covering the meropenem concentration range of 0.5–200 μg/ml. The detection limit and the relative standard deviation of the migration times and of the peak areas were determined.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(99)00100-4