Feto-maternal ACP1 activity ratio and intrauterine survival

Abstract Objective Genetic differences in the activity of phosphotyrosine phosphatases between mother and embryo could result in a differential activation of signals induced by growth factors in the two sides of placenta. Previous observations suggest that this may have important effects on intraute...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2008-09, Vol.140 (1), p.12-16
Main Authors: Gloria-Bottini, F, Meloni, G.F, Nicotra, M, Saccucci, P, Stampone, L, Bottini, N, Lista, F, Bottini, E
Format: Article
Language:English
Subjects:
Abortion, Habitual - enzymology
ACP1
Case-Control Studies
Female
Fetal survival
Feto-maternal ACP1 activity ratio
Genotype
Humans
Infant, Newborn
Isoenzymes - blood
Isoenzymes - genetics
Male
Obstetrics and Gynecology
Phenotype
Pregnancy
Pregnancy in Diabetics
Protein Tyrosine Phosphatases - blood
Protein Tyrosine Phosphatases - genetics
Proto-Oncogene Proteins - blood
Proto-Oncogene Proteins - genetics
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Summary:Abstract Objective Genetic differences in the activity of phosphotyrosine phosphatases between mother and embryo could result in a differential activation of signals induced by growth factors in the two sides of placenta. Previous observations suggest that this may have important effects on intrauterine development and survival. The aim of the present study is to confirm previous observations and show new data. Study design We have studied 573 mother/newborn pairs, 169 wife/husband couples with repeated spontaneous abortion and 34 fertile wife/husband couples Results In mother/newborn pairs, the analysis of joint mother/infant ACP1 distribution has shown a deficit of pairs with the mother having low ACP1 S isoform concentration and the infant having high S isoform concentration, and an excess of pairs with the mother having high S isoform concentration and the infant having low S isoform concentration. In RSA couples there is an excess of couples in which the wife has low S isoform concentration and the husband has high S isoform concentration and a deficit of couples in which the wife has high S isoform concentration and the husband has low S isoform concentration. In fertile couples the pattern is reversed. Conclusion The data suggest that when the mother to fetus S isoform concentration ratio is in favour of the mother, the probability of survival of the fetus is greater than in the opposite situation.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2006.03.025