High density oligonucleotide and DNA probe arrays for the analysis of target DNA

The acquisition of sequence, expression and other information concerning genetic material constitutes a crucial component of the modern revolution in molecular biology. One important advance in this area is the development of high density oligonucleotide/DNA microarrays which allows the rapid sequen...

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Bibliographic Details
Published in:Analyst (London) 1999-08, Vol.124 (8), p.1133-1136
Main Authors: THOMPSON, M, FURTADO, L. M
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
DNA Probes
Dna, deoxyribonucleoproteins
Fundamental and applied biological sciences. Psychology
Gene Targeting
In Situ Hybridization
Nucleic acids
Oligonucleotide Array Sequence Analysis
Oligonucleotide Probes
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Summary:The acquisition of sequence, expression and other information concerning genetic material constitutes a crucial component of the modern revolution in molecular biology. One important advance in this area is the development of high density oligonucleotide/DNA microarrays which allows the rapid sequence analysis of genomic target samples in addition to diagnostic possibilities with respect to genetic and infectious disease. In the present article we review protocols for the design of such microarrays and their principles of operation. Together with a look at some recent applications we include brief remarks as to the possibilities for the future.
ISSN:0003-2654
1364-5528
DOI:10.1039/a904581c