Capillary electrophoresis as a versatile tool for the bioanalysis of drugs—a review

This review article presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The principles of capillary electrophoresis and its various separation and detection modes are briefly discussed. Sample pretreatment meth...

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Bibliographic Details
Published in:Journal of Pharmaceutical and Biomedical Analysis 1999-09, Vol.20 (6), p.831-863
Main Authors: Boone, C.M, Waterval, J.C.M, Lingeman, H, Ensing, K, Underberg, W.J.M
Format: Article
Language:English
Subjects:
Analysis
Bioanalysis
Biological and medical sciences
Capillary electrophoresis
Chromatography, Micellar Electrokinetic Capillary - methods
Detection limit
Drugs
Electrophoresis, Capillary - instrumentation
Electrophoresis, Capillary - methods
General pharmacology
Humans
Medical sciences
Micellar electrokinetic chromatography
Pharmaceutical Preparations - chemistry
Pharmacology. Drug treatments
Review
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Summary:This review article presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The principles of capillary electrophoresis and its various separation and detection modes are briefly discussed. Sample pretreatment methods which have been used for clean-up and concentration are discussed. Finally, an extensive overview of bioanalytical applications is presented. The bioanalyses of more than 200 drugs have been summarised, including the applied sample pretreatment methods and the achieved detection limits.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(99)00088-6