Determination of nicarbazin in feeds using liquid chromatography-electrospray mass spectrometry

A method is presented for the determination of the 4,4'-dinitrocarbanilide component of the coccidiostat nicarbazin in animal feeds. Samples are extracted by shaking with methanol and analysed, without further clean-up, using liquid chromatography-electrospray mass spectrometry. A deuterated fo...

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Bibliographic Details
Published in:Analyst (London) 1999-10, Vol.124 (10), p.1431-1434
Main Authors: CANNAVAN, A, BALL, G, KENNEDY, D. G
Format: Article
Language:English
Subjects:
Animal Feed - analysis
Biological and medical sciences
Chromatography, Liquid
Coccidiostats - analysis
Feed and pet food industries
Food industries
Fundamental and applied biological sciences. Psychology
Mass Spectrometry
Nicarbazin - analysis
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Summary:A method is presented for the determination of the 4,4'-dinitrocarbanilide component of the coccidiostat nicarbazin in animal feeds. Samples are extracted by shaking with methanol and analysed, without further clean-up, using liquid chromatography-electrospray mass spectrometry. A deuterated form of the analyte is employed as internal standard to improve the repeatability of the method. The method has been validated at levels between 0.1 and 100 mg kg-1 with internal standard corrected recoveries between 88 and 101% and RSD values < 8%.
ISSN:0003-2654
1364-5528
DOI:10.1039/a904557k