Leptin, adiponectin, resistin, and ghrelin - Implications for inflammatory bowel disease

Inflammatory bowel disease (IBD) is characterized by anorexia, malnutrition, altered body composition, and development of mesenteric white adipose tissue (WAT) hypertrophy. Increasing evidence suggests that adipokines synthesized either in WAT or in immune cells, are involved in these manifestations...

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Bibliographic Details
Published in:Molecular nutrition & food research 2008-08, Vol.52 (8), p.855-866
Main Authors: Karmiris, Konstantinos, Koutroubakis, Ioannis E, Kouroumalis, Elias A
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - physiology
Adipose Tissue, White - pathology
Animals
Colitis, Ulcerative - pathology
Crohn Disease - pathology
Cytokines - biosynthesis
Ghrelin
Ghrelin - physiology
Humans
Hypertrophy
Inflammatory bowel disease
Inflammatory Bowel Diseases - etiology
Leptin
Leptin - physiology
Resistin
Resistin - physiology
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Summary:Inflammatory bowel disease (IBD) is characterized by anorexia, malnutrition, altered body composition, and development of mesenteric white adipose tissue (WAT) hypertrophy. Increasing evidence suggests that adipokines synthesized either in WAT or in immune cells, are involved in these manifestations of IBD. Among adipokines leptin, adiponectin and resistin hold a fundamental role while the role of ghrelin in inflammation is not well established. Preliminary studies have shown overexpression of leptin, adiponectin, and resistin in mesenteric WAT of patients with Crohn's disease (CD) and significant alterations of circulating serum levels of these adipokines in IBD. It has also been demonstrated that intestinal inflammation causes an increase in endogenous ghrelin production. In animal models of intestinal inflammation, existing data suggest that leptin, adiponectin, and resistin are pivotal mediators of inflammation. Interesting therapeutic interventions based on these data have been suggested. A specific role for hypertrophic WAT has also been implicated in CD. Further efforts with experimental and clinical studies are needed to better understand the role of adipokines in IBD.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.200700050