Esophageal lichen planus: the Mayo Clinic experience

Lichen planus (LP) is an inflammatory papulosquamous disease which may affect the squamous epithelium of the esophagus. We reviewed six patients with esophageal lichen planus (ELP) seen at Mayo Clinic Rochester between 1984 and 1998. The presenting symptoms were dysphagia (in all six patients) and o...

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Bibliographic Details
Published in:Diseases of the esophagus 1999-01, Vol.12 (4), p.309-311
Main Authors: Harewood, G C, Murray, J A, Cameron, A J
Format: Article
Language:English
Subjects:
Adult
Aged
Biopsy, Needle
Esophageal Diseases - diagnosis
Esophageal Diseases - drug therapy
Esophageal Diseases - pathology
Esophagoscopy
Female
Glucocorticoids - administration & dosage
Hospitals, University
Humans
Lichen Planus - diagnosis
Lichen Planus - drug therapy
Lichen Planus - pathology
Middle Aged
Minnesota
Prednisone - administration & dosage
Prognosis
Retrospective Studies
Treatment Outcome
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Description
Summary:Lichen planus (LP) is an inflammatory papulosquamous disease which may affect the squamous epithelium of the esophagus. We reviewed six patients with esophageal lichen planus (ELP) seen at Mayo Clinic Rochester between 1984 and 1998. The presenting symptoms were dysphagia (in all six patients) and odynophagia (two patients). Cervical esophageal strictures were seen in four patients; average number of esophageal dilatations required was 15 (range, 10–18). Esophageal biopsies demonstrated the classical histologic findings of ELP in two patients, and a lymphocytic infiltrate in the other four. Concomitant lichen planus (LP) was seen at other sites in five patients: all five had oral LP preceeded by ELP symptoms in all five; three had genital LP preceeded by ELP symptoms in all three; two had dermal LP, preceeded by ELP symptoms in one. Proton pump inhibitors were tried unsuccessfully in all patients. Four patients were started on systemic steroid medication; three had resolution of symptoms within 1 month.
ISSN:1120-8694
1442-2050
DOI:10.1046/j.1442-2050.1999.00073.x