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The role of the epidermal growth factor receptor in microbial infections of the gastrointestinal tract

The epidermal growth factor receptor (EGFr) is a transmembrane glycoprotein with an intrinsic tyrosine kinase. Ligand-binding to the EGFr activates cell signaling, phosphorylates protein kinases, and rearranges cytoskeletal proteins – responses that resemble those induced by microbial attachment to...

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Published in:	Microbes and Infection 1999-11, Vol.1 (13), p.1139-1144
Main Authors:	Buret, Andre, Gall, D.Grant, Olson, Merle E., Hardin, James A.
Format:	Article
Language:	English
Subjects:	Animals Bacteria - metabolism Bacteria - pathogenicity Bacterial Infections - metabolism Bacterial Infections - microbiology Biological and medical sciences epidermal growth factor epidermal growth factor receptors epithelial Eukaryota - metabolism Eukaryota - pathogenicity gastrointestinal Gastrointestinal Diseases - metabolism Gastrointestinal Diseases - microbiology Gastrointestinal Diseases - parasitology Gastrointestinal Diseases - virology General aspects Human infectious diseases. Experimental studies and models Humans infection Infectious diseases Medical sciences Protozoan Infections - metabolism Protozoan Infections - parasitology Receptor, Epidermal Growth Factor - metabolism Virus Diseases - metabolism Virus Diseases - virology Viruses - metabolism Viruses - pathogenicity
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description	The epidermal growth factor receptor (EGFr) is a transmembrane glycoprotein with an intrinsic tyrosine kinase. Ligand-binding to the EGFr activates cell signaling, phosphorylates protein kinases, and rearranges cytoskeletal proteins – responses that resemble those induced by microbial attachment to cell surfaces, a process known to be mediated by host cell receptors in a number of cases. This article critically reviews the possible role played by the EGFr in microbial colonization, and discusses how modulation of the EGF-EGFr axis may affect infection of the gastrointestinal tract.
doi_str_mv	10.1016/S1286-4579(99)00201-4
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subjects	Animals Bacteria - metabolism Bacteria - pathogenicity Bacterial Infections - metabolism Bacterial Infections - microbiology Biological and medical sciences epidermal growth factor epidermal growth factor receptors epithelial Eukaryota - metabolism Eukaryota - pathogenicity gastrointestinal Gastrointestinal Diseases - metabolism Gastrointestinal Diseases - microbiology Gastrointestinal Diseases - parasitology Gastrointestinal Diseases - virology General aspects Human infectious diseases. Experimental studies and models Humans infection Infectious diseases Medical sciences Protozoan Infections - metabolism Protozoan Infections - parasitology Receptor, Epidermal Growth Factor - metabolism Virus Diseases - metabolism Virus Diseases - virology Viruses - metabolism Viruses - pathogenicity
title	The role of the epidermal growth factor receptor in microbial infections of the gastrointestinal tract
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