Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle

31P magnetic resonance spectroscopy (MRS) offers a unique non-invasive window on energy metabolism in skeletal muscle, with possibilities for longitudinal studies and of obtaining important bioenergetic data continuously and with sufficient time resolution during muscle exercise. The present paper p...

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Published in:Proceedings of the Nutrition Society 1999-11, Vol.58 (4), p.861-870
Main Authors: Heerschap, A., Houtman, C., in 't Zandt, H. J. A., van den Bergh, A. J., Wieringa, B.
Format: Article
Language:English
Subjects:
31P magnetic resonance spectroscopy
Animals
Energy Metabolism
Exercise
Exercise - physiology
High-energy phosphates
Humans
Hydrogen-Ion Concentration
Kinetics
Magnetic Resonance Spectroscopy
Muscle, Skeletal - metabolism
Phosphorus Isotopes
Skeletal muscle
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container_issue 4
container_start_page 861
container_title Proceedings of the Nutrition Society
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creator Heerschap, A.
Houtman, C.
in 't Zandt, H. J. A.
van den Bergh, A. J.
Wieringa, B.
description 31P magnetic resonance spectroscopy (MRS) offers a unique non-invasive window on energy metabolism in skeletal muscle, with possibilities for longitudinal studies and of obtaining important bioenergetic data continuously and with sufficient time resolution during muscle exercise. The present paper provides an introductory overview of the current status of in vivo 31P MRS of skeletal muscle, focusing on human applications, but with some illustrative examples from studies on transgenic mice. Topics which are described in the present paper are the information content of the 31P magnetic resonance spectrum of skeletal muscle, some practical issues in the performance of this MRS methodology, related muscle biochemistry and the validity of interpreting results in terms of biochemical processes, the possibility of investigating reaction kinetics in vivo and some indications for fibre-type heterogeneity as seen in spectra obtained during exercise.
doi_str_mv 10.1017/S0029665199001160
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subjects 31P magnetic resonance spectroscopy
Animals
Energy Metabolism
Exercise
Exercise - physiology
High-energy phosphates
Humans
Hydrogen-Ion Concentration
Kinetics
Magnetic Resonance Spectroscopy
Muscle, Skeletal - metabolism
Phosphorus Isotopes
Skeletal muscle
title Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle
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